Chronic Lymphocytic Leukaemia: An Overview of Aetiology in Light of Recent Developments in Classification and Pathogenesis

Details

• Personal Author:
  Blair, Austin ; Caldwell G ; Dores GM ; Field RW ; Hatch M ; Landgren O ; Linet MS ; Richardson DB ; Schubauer-Berigan, Mary K. ; Silver S ; Weisenburger DD
• Description:
  This overview of the epidemiology of chronic lymphocytic leukaemia (CLL) summarizes the evolution of classification and coding systems and describes the intersection of pathogenesis and aetiology. The role of the putative precursor to CLL, monoclonal B-cell lymphocytosis (MBL), is considered, and ideas for future investigations of the MBL-CLL relationship are outlined. We discuss the epidemiology of CLL, focusing on descriptive patterns and methodological considerations. Postulated risk factors are reviewed including the role of ionizing and non-ionizing radiation, occupational and environmental chemical exposures, medical conditions and treatments, and lifestyle and genetic factors. We conclude by raising key questions that need to be addressed to advance our understanding of CLL aetiology. Recommendations for future epidemiological studies are given, including the standardization of reporting of CLL across cancer registries, the clarification of the natural history of MBL, and the circumvention of the methodological shortcomings of prior epidemiological investigations in relation to radiation, chemical exposures and infectious agents. [Description provided by NIOSH]
• Subjects:
  Blood Chemistry Communicable Diseases Epidemiology Genetics Hypersensitivity Lymphatic System Neoplasms Occupational Health Radiation Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Cancer-rates Chemical-hypersensitivity Chemical-properties Chemical-synthesis Chemoreceptors Genes Infectious-diseases Leukemogenesis Lymphatic-cancer Lymphatic-system-disorders Pathogenicity Radiation-effects Radiation-exposure Radiation-hazards Radiation-levels Radiation-measurement Radiation-monitoring Risk-analysis Risk-factors

  More +
• ISSN:
  0007-1048
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Kentucky ; Maryland ; Nebraska ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  139
• Issue:
  5
• NIOSHTIC Number:
  nn:20032888
• Citation:
  Br J Haematol 2007 Dec; 139(5):672-686
• Contact Point Address:
  Martha S. Linet, NCI, DCEG, Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd. EPS Room 7048, Bethesda, MD 20892-7238
• Email:
  linetm@mail.nih.gov
• Federal Fiscal Year:
  2008
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  British Journal of Haematology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0a12d5d3b7314f56e19884459e7769db4dd82f2037c6992e729fb5f46cd21ff9fcb13b737ca21f3454efac4c0771c22d5443ea4cdb166e36f95d2bdcd9641362
• Download URL:
  https://stacks.cdc.gov/view/cdc/186687/cdc_186687_DS1.pdf
• File Type:
  [PDF - 169.10 KB ]