Epidemiologic Evaluation of Childhood Leukemia and Paternal Exposure to Ionizing Radiation

Details

• Personal Author:
  Buchanan J ; Gilbert ES ; Greaves C ; Greaves J ; Sever LE ; Tucker K
• Description:
  This project examined cases of three major categories of childhood cancers in the populations around three United States Department of Energy (DOE) facilities to examine the hypothesis of an association between childhood cancer risk and paternal preconception of occupational radiation exposure. This hypothesis was based on the finding of such an association in the population around the Sellafield nuclear facility in England (Gardner et al. 1990a). In an attempt to identify the cause of a cluster of childhood cancers in the vicinity of the Sellafield nuclear plant in West Cumbria, Gardner et a!. (1990a, 1990b) conducted a case-control study of cases of leukemia and non-Hodgkin's lymphoma. Examining a wide variety of risk factors, the authors demonstrated that relative risks for leukemia and non-Hodgkin's lymphoma were higher in children born near Sellafield and in children of fathers employed at the facility, particularly fathers with high radiation dose recordings before conception. Gardner et al. (1990a, 1990b) included all known cases of leukemia and non-Hodgkin's lymphoma among residents of the West Cumbria Health Authority who were diagnosed between the years of 1950 and 1985, were born in the area, and were under the age of 25 years at the time of diagnosis. [Description provided by NIOSH]
• Subjects:
  Blood Case Reports Lymphatic System Neoplasms Nuclear Power Plants Occupational Health Radiation Risk Assessment Risk Factors Safety
• Keywords:
  Cancer Cancer-rates Case-studies Children Leukemogenesis Lymphatic-system-disorders Nuclear-energy Nuclear-power-plants Radiation-exposure Radiation-facilities Risk-factors

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• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-51
• NIOSHTIC Number:
  nn:20023777
• NTIS Accession Number:
  PB2008-101050
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U50-CCU-012545, 1997 Oct; :1-51
• Contact Point Address:
  Battelle Memorial Institute, Seattle Research Center, 4000 N. E. 41st Street, Seattle, WA 98105
• Federal Fiscal Year:
  1998
• NORA Priority Area:
  Research Tools and Approaches: Risk Assessment Methods
• Performing Organization:
  Battelle Memorial Institute, Seattle Research Center
• Peer Reviewed:
  False
• Start Date:
  19920901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19970331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c44d0d7158cb93a94089743175e40b544a62dce565f8fc77b482f996b3f10cab2a36946bde89ce56e3639926b2b368bc2878bfac791db041d8d44394474f4428
• Download URL:
  https://stacks.cdc.gov/view/cdc/218122/cdc_218122_DS1.pdf
• File Type:
  [PDF - 2.48 MB ]