Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Roy, Soumitra ; Sandhu, Arbansjit ; Medina, Angelica ; Clawson, David S. ; Wilson, James M.
Roy, Soumitra ; Sandhu, Arbansjit ; Medina, Angelica ; Clawson, David S. ; Wilson, James M. Less -
Description:
Adenoviruses can cause infectious diarrheal disease or respiratory infections in humans; 2 recent reports have indicated probable human infection with simian adenoviruses (SAdVs). To assess the possibility of animal-to-human transmission of SAdVs, we tested fecal samples from asymptomatic rhesus macaques housed in 5 primate facilities in the United States and cultured 23 SAdV isolates. Of these, 9 were purified and completely sequenced; 3 SAdV samples from the American Type Culture Collection (SAdV-6, SAdV-18, and SAdV-20) were also completely sequenced. The sequence of SAdV-18 was closely related to that of human adenovirus F across the whole genome, and the new isolates were found to harbor 2 fiber genes similar to those of human adenovirus (HAdV) strains HAdV-40 and HAdV-41, which can cause infectious diarrhea. The high prevalence of adenoviruses in fecal samples from asymptomatic rhesus macaques and the similarity of the isolates to human strains indicates the possibility of animal-to-human transmission of SAdVs.
Subject:
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Adenoviridae Infections
Adenoviruses, Simian
Amino Acid Sequence
Animals
DNA, Viral
Feces
Humans
Macaca Mulatta
Molecular Sequence Data
Monkey Diseases
Phylogeny
Polymerase Chain Reaction
Sequence Alignment
Sequence Analysis, DNA
Zoonoses

Source:
Emerg Infect Dis. 18(7):1081-1088.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:fe97770a7c967a22bcc12a093608c07648919f5e9a0b0579c60e66555705767f
File Type:

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