Pulmonary Function and Exercise-Associated Changes with Chronic Low-Level Paraquat Exposure

Details

• Personal Author:
  Beckett LA ; Enright, Paul L. ; Hennessy T ; Lee K ; Lupercio R ; Schenker MB ; Stoecklin M ; Zeballos RJ
• Description:
  The present study was undertaken to test the hypothesis that chronic, low-level paraquat exposure causes restrictive lung function with gas transfer impairment. Three hundred thirty-eight Costa Rican farm workers from banana, coffee, and palm oil farms completed a questionnaire, spirometry, and a test of single-breath carbon monoxide diffusing capacity. Subjects 40 years of age or older, without other medical risk factors, completed maximal cardiopulmonary exercise tests. Most (66.6%) were paraquat handlers; 24.8% of handlers and 27.3% of nonhandlers reported current cigarette smoking. In linear regression models, cumulative paraquat exposure was not an independent predictor of VA, carbon monoxide diffusing capacity, peak oxygen uptake, FVC, or oxygen pulse peak. However, the ventilatory equivalent for CO(2), although within normal range, was significantly higher with increased cumulative paraquat exposure. Oxygen desaturation greater than 5% from rest to peak exercise had an odds ratio of 1.7 (95% confidence interval = 0.9-3.0) with the cumulative paraquat exposure index in models adjusted for age, weight, and smoking status. The association of paraquat exposure with ventilatory equivalent and oxygen desaturation suggests that paraquat may be associated with subclinical gas exchange abnormalities, but overall these findings are consistent with no clinically significant increases in interstitial thickening or restrictive lung disease among this population. [Description provided by NIOSH]
• Subjects:
  Agriculture Epidemiology Farmers Insecticides Occupational Health Respiratory Tract Diseases Safety Surveys And Questionnaires
• Keywords:
  Agricultural-chemicals Agricultural-industry Agricultural-workers Humans Pesticides Pesticides-and-agricultural-chemicals Pulmonary-system-disorders Questionnaires Respiratory-system-disorders Statistical-analysis
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  170
• Issue:
  7
• NIOSHTIC Number:
  nn:20032829
• Citation:
  Am J Respir Crit Care Med 2004 Oct; 170(7):773-779
• Contact Point Address:
  Marc B. Schenker, M.D., M.P.H., University of California, Davis, Department of Epidemiology and Preventive Medicine, One Shields Avenue, TB168, Davis, CA 95616
• Email:
  mbschenker@ucdavis.edu
• CAS Registry Number:
  Methyl viologen (CAS RN 1910-42-5)
• Federal Fiscal Year:
  2005
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  19900930
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ec0a634dd095d6f3ccd0e0441c41fd39211dee633e4f2eebebcb561b847a133a030b810ac5cc857796a8c4f64de672d8a8df5aad456602ccf05de468e889a7ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/186654/cdc_186654_DS1.pdf
• File Type:
  [PDF - 94.68 KB ]