Pesticides and Other Agricultural Factors Associated with Self-Reported Farmer’s Lung Among Farm Residents in the Agricultural Health Study

Details

• Personal Author:
  Alavanja MCR ; Henneberger, Paul K. ; Hoppin JA ; Kullman, Greg J. ; London SJ ; Sandler DP ; Umbach DM
• Description:
  Background: Farmer's lung, or hypersensitivity pneumonitis, is an important contributor to respiratory morbidity among farmers. Methods: Using the 1993 - 7 enrolment data from the Agricultural Health Study, we conducted a cross-sectional study of occupational risk factors for farmer's lung among, 50,000 farmers and farm spouses in Iowa and North Carolina using hierarchical logistic regression controlling for age, state, and smoking status. Participants provided information on agricultural exposures, demographic characteristics, and medical history via self- administered questionnaires. Approximately 2% of farmers (n = 481) and 0.2% of spouses (n = 51) reported doctor- diagnosed farmer's lung during their lifetime. We assessed farmers and spouses separately due to different information on occupational exposure history. Only pesticide exposures represented lifetime exposure history, all other farm exposures represented current activities at enrolment. Results: Among farmers, handling silage (OR = 1.41, 95% CI 1.10 to 1.82), high pesticide exposure events (OR = 1.75, 95% CI 1.39 to 2.21), and ever use of organochlorine (OR = 1.34, 95% CI 1.04 to 1.74) and carbamate pesticides (OR = 1.32, 95% CI 1.03 to 1.68) were associated with farmer's lung in mutually-adjusted models. The insecticides DDT, lindane, and aldicarb were positively associated with farmer's lung among farmers. Current animal exposures, while not statistically significant, were positively associated with farmer's lung, particularly for poultry houses (OR = 1.55, 95% CI 0.93 to 2.58) and dairy cattle (OR = 1.28, 95% CI 0.86 to 1.89). The occupational data were more limited for spouses; however, we saw similar associations for dairy cattle (OR = 1.50, 95% CI 0.72 to 3.14) and organochlorine pesticides (OR = 1.29, 95% CI 0.64 to 2.59). Conclusion: While historic farm exposures may contribute to the observed associations with pesticides, these results suggest that organochlorine and carbamate pesticides should be further evaluated as potential risk factors for farmer's lung. [Description provided by NIOSH]
• Subjects:
  Agriculture Epidemiology Farmers Insecticides Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Surveys And Questionnaires

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• Keywords:
  Agricultural-chemicals Agricultural-workers Lung-disorders Lung-irritants Mathematical-models Pesticides-and-agricultural-chemicals Pulmonary-disorders Pulmonary-function Pulmonary-system-disorders Questionnaires Respiratory-system-disorders Statistical-analysis

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  334-342
• Volume:
  64
• Issue:
  5
• NIOSHTIC Number:
  nn:20032112
• Citation:
  Occup Environ Med 2007 May; 64(5):334-342
• Contact Point Address:
  Jane Hoppin, NIEHS, Epidemiology Branch, MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709-2233
• Email:
  hoppin1@niehs.nih.gov
• CAS Registry Number:
  Aldicarb (CAS RN 116-06-3) ; DDT (CAS RN 50-29-3) ; Lindane (CAS RN 58-89-9)
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9ad210c14ff4ed1e132f51e3094fb4c19fca648fa51205b13c7ef156160d9ea37b09b43dc45976e39f0fcf633fc46db41a7d22af910170e5fd1ef8e851bb3c78
• Download URL:
  https://stacks.cdc.gov/view/cdc/186164/cdc_186164_DS1.pdf
• File Type:
  [PDF - 195.66 KB ]