Clinical Blood Cholinesterase Measurements for Monitoring Pesticide Exposures

Details

• Personal Author:
  Billitti JE ; Henderson JD ; Padilla S ; Sanborn JR ; Wilson BW
• Description:
  Measurement of blood cholinesterase (ChE) activity, especially acety1cholinesterases (AChE, EC 3.1.1.7) and butyrylcholinesterases (BChE, EC 3.1.1.8), is of worldwide interest and importance. They are one of the few biomarkers that function both as an indicator of exposure and also as evidence of an adverse effect. Determining blood ChEs is required for monitoring farm workers in the state of California in the United States. In addition, ChE determinations are used in emergency wards to diagnose exposure to anti-ChEs, as part of the submissions to regulatory agencies to set safe levels of pesticides, to monitor wildlife and their exposure to dangerous anti-ChE chemicals, and to provide evidence of the use or escape of nerve gases. Recently the reliability ofChE data submitted for regulatory and diagnostic purposes has been examined by the US and California Environmental Protection Agencies. Issues raised included variability of clinical laboratory results (Christenson et aI., 1994; Wilson et aI., 1992) and lack of validated and interlaboratory standard operating procedures. This paper reviews our recent experiences in examining the reliability ofthiocholine ester colorimetric assays, modified from the assay of Ellman et al. (1961), in the monitoring of blood ChEs from humans, domestic animals and wildlife. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Blood Cholinesterase Inhibitors Diagnosis Environmental Monitoring Farmers Hematologic Tests Insecticides Occupational Health Safety

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• Keywords:
  Acetylcholinesterase Agricultural-chemicals Agricultural-workers Animal-studies Blood-analysis Blood-samples Blood-tests Cholinesterase-inhibitors Diagnostic-techniques Diagnostic-tests Exposure-assessment Exposure-levels Exposure-limits Pesticides Pesticides-and-agricultural-chemicals

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• ISBN:
  0306451352
• Publisher:
  Plenum Press
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Book
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  329-336
• NIOSHTIC Number:
  nn:20032790
• Citation:
  Enzymes of Cholinesterase Family. Quinn DM, ed., New York: Plenum Press, 1995 Oct; :329-335
• Contact Point Address:
  University of California Davis, California 95616
• Editor(s):
  Quinn DM
• Federal Fiscal Year:
  1996
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  False
• Start Date:
  19900930
• Source Full Name:
  Enzymes of Cholinesterase Family
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e3c7466f2618919afe6d03b4c606253d30de606fa9707301860c467715b113918b4f5ce5fe4836c53e4d3e8d2fb6ba2c9e2b8c7b718fe25193f560b4273487a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/186631/cdc_186631_DS1.pdf
• File Type:
  [PDF - 644.21 KB ]