In Vitro System for Applying Cyclic Loads to Connective Tissues Under Displacement or Force Control

Details

• Personal Author:
  Asundi KR ; Kursa K ; Lotz J ; Rempel DM
• Description:
  Overuse is thought to be the primary cause of chronic tendon injuries, in which forceful or repetitive loading results in an accumulation of micro-tears leading to a maladaptive repair response. In vitro organ culture models provide a useful method for examining how specific loading patterns affect the cellular response to load which may explain the early mechanisms of tissue injury associated with tendinopathies and ligament injuries. We designed a novel tissue loading system which employs closed-loop force feedback, capable of loading six tissue samples independently under force or displacement control. The system was capable of applying loads up to 40 N at rates of 100 N s(-1) and frequencies of 2 Hz, well above loads and rates measured in rabbit tendons in vivo. Loading parameters such as amplitude, rate, and frequency can be controlled while biomechanical factors such as creep, force relaxation, tangent modulus and Young's modulus can be assessed. The system can be used to examine the relationship between each loading parameter and biomechanical factors of connective tissues maintained in culture which may provide useful information regarding the etiology of overuse injuries. [Description provided by NIOSH]
• Subjects:
  Biomechanical Phenomena Environmental Monitoring Ergonomics Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Overuse Injuries Biological-effects Biological-function Biomechanical-engineering Biomechanical-modeling Biomechanics Bioreactor Cell-biology Cellular-reactions Exposure-assessment Exposure-levels Exposure-methods In-vitro-studies In-vitro-study Laboratory-animals Laboratory-testing Mechanical Stimulation Mechanics Musculoskeletal-system Musculoskeletal-system-disorders Organ Culture Physiological-effects Physiological-measurements Physiological-response Quantitative-analysis Repetitive-work Risk-analysis Risk-factors Statistical-analysis Tendinopathies Tension Tissue-disorders

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• ISSN:
  0090-6964
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  7
• NIOSHTIC Number:
  nn:20032487
• Citation:
  Ann Biomed Eng 2007 Jul; 35(7):1188-1195
• Contact Point Address:
  David M. Rempel, Ergonomics Program, Department of Bioengineering, University of California at Berkeley, 1301 South 46th Street, Building 163, Richmond, CA 94804
• Email:
  david.rempel@ucsf.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Biomedical Engineering
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:87e8f23beb43f2dc15f5c26c412cccaeb0d048d9a5bbeb58228c0cf1d7f8fdd6cd05a65ec02898085d89ef18e31c713cc13dfc27efa42ceb3d6845a948c1352a
• Download URL:
  https://stacks.cdc.gov/view/cdc/186432/cdc_186432_DS1.pdf
• File Type:
  [PDF - 501.97 KB ]