Antioxidant Activity of Vaccinium stamineum: Exhibition of Anticancer Capability in Human Lung and Leukemia Cells

Details

• Personal Author:
  Ballington JR ; Bowman L ; Ding M ; Feng RT ; Lu YJ ; Wang SY
• Description:
  Fruit of deerberry [Vaccinium stamineum L.] were evaluated for their antioxidant capacity and anticancer properties in JB6 P+ mouse epidermal cells, human lung and leukemia cells. Deerberries contain potent free radical scavenging activities. Pretreatment of JB6 P+ mouse epidermal cells with deerberry fruit extracts produced an inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappa B) induced by either 12-0-tetradecanoylphorbol 13-acetate (TPA) or ultraviolet-B (UVB). Deerberry fruit extracts also blocked TPA- or UVB-induced phosphorylation of ERKs and MEK 1/2, two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells. These results suggest that the inhibition of TPA- or UVB-induced AP-1 and NF-kappa B activity, inhibition of HL-60 cells and cancer A549 cells proliferation and induction of apoptotic in human leukemia HL-60 cancer cel Is may be mediated through the ERKs and MEK 1/2 signal pathway. [Description provided by NIOSH]
• Subjects:
  Animals Antibodies Antigens Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Analytical-methods Analytical-processes Animal-studies Antibody-response Cancer Humans Leukocytes Lung-cancer Lung-cells Lung-disease Lung-tissue Sensitivity-testing

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• ISSN:
  0032-0943
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; OSHA Region 4 ; South Carolina ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  451-460
• Volume:
  73
• Issue:
  5
• NIOSHTIC Number:
  nn:20032382
• Citation:
  Planta Med 2007 May; 73(5):451-460
• Contact Point Address:
  SY Wang, USDA ARS, Beltsville Agriculture Research Center, Agriculture Research Service, Fruit Laboratory, Beltsville, MD 20705
• Email:
  wangs@ba.ars.usda.gov
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Planta Medica
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dd2581fb553a25753c6fe4f8c11f229b2e36e46fa77960c539e6ea610749517ced4f926e92e21b496b0c3d88b14d95be0719e138c6d08d87a69eff4909a33623
• Download URL:
  https://stacks.cdc.gov/view/cdc/186386/cdc_186386_DS1.pdf
• File Type:
  [PDF - 667.74 KB ]