Variations in Free Radical Scavenging Capacity and Antiproliferative Activity Among Different Genotypes of Autumn Olive (Elaeagnus umbellata)

Details

• Personal Author:
  Bowman L ; Ding M ; Wang SY
• Description:
  Fruit from six genotypes of autumn olive (Elaeagnus umbellata Thunb.) ('Brilliant Rose', 'Delightful', 'Jewel', Natural 1, Natural 2, and 'Sweet Tart') were evaluated for antioxidant capacity and anti-cancer properties. Based on data from electron spin resonance (ESR) measurements, autumn olive contained potent free radical scavenging activities for hydroxyl (OH) and superoxide (O2(-)) radicals. Among the six genotypes, 'Brilliant Rose' and 'Jewel' had the highest levels of antioxidant activity. Pretreatment of JG6 P+ mouse epidermal cells with autumn olive extracts inhibited the activation of activator protem-1 (AP-1) and nuclear factoF-kappaB (NF-kappa B) induced by either 12-O-tetradecanoyl- phorbol 13-acetate (TPA) or ultraviolet-B (UVB). Extracts of all autumn olive genotypes inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells. In particular, 'Brilliant Rose' and 'Jewel' had relatively potent activities compared to other genotypes. These results indicate that consuming autumn olive fruit may be beneficial to human health, although further studies are needed for confirmation. [Description provided by NIOSH]
• Subjects:
  Antibodies Antigens Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Analytical-methods Analytical-processes Antibody-response Cancer Cell-biology Cell-function Cell-metabolism Cellular-transport-mechanism Humans Leukocytes Lung-cancer Lung-cells Lung-disease Lung-tissue Sensitivity-testing

  More +
• ISSN:
  0032-0943
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  468-477
• Volume:
  73
• Issue:
  5
• NIOSHTIC Number:
  nn:20032414
• Citation:
  Planta Med 2007 May; 73(5):468-477
• Contact Point Address:
  SY Wang, USDA ARS, Beltsville Agriculture Research Center, Agriculture Research Service, Fruit Laboratory, Beltsville, MD 20705
• Email:
  wangs@ba.ars.usda.gov
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Planta Medica
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:52d385e2fe8d1d032add25c9c363c2ca93279ff35b0ecbb550f5baedc0cc747cd807ba6a811d8de09c5c6fcec2b8b030197c6eec673dd1c1d6aa5926c94c1728
• Download URL:
  https://stacks.cdc.gov/view/cdc/186398/cdc_186398_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]