Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pournaras, Spyros ; Ntokou, Eleni ; Zarkotou, Olympia ; Ranellou, Kyriaki ; Themeli-Digalaki, Katerina ; Stathopoulos, Constantinos ; Tsakris, Athanassios
• Description:
  We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.
• Subjects:
  Acetamides Adult Aged Amino Acid Substitution Anti-Bacterial Agents Dispatch DNA, Bacterial Drug Resistance, Bacterial Female Humans Male Microbial Sensitivity Tests Middle Aged Oxazolidinones Point Mutation Ribosomal Proteins RNA, Ribosomal, 23S Serotyping Staphylococcal Infections

  More +
• Source:
  Emerg Infect Dis. 19(1):129-132.
• Document Type:
  Journal Article
• Place as Subject:
  Greece
• Location:
  Europe
• Volume:
  19
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:eaed4c99e26cb8350ce4b7e44b3cfbf8db3ba35aa7f5647926b51da69d69b785
• Download URL:
  https://stacks.cdc.gov/view/cdc/18638/cdc_18638_DS1.pdf
• File Type:
  [PDF - 532.96 KB ]