Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Pournaras, Spyros; Ntokou, Eleni; Zarkotou, Olympia; Ranellou, Kyriaki; Themeli-Digalaki, Katerina; Stathopoulos, Constantinos; Tsakris, Athanassios

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Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Jan 2013
By Pournaras, Spyros ; Ntokou, Eleni ; Zarkotou, Olympia ; ...
Source: Emerg Infect Dis. 19(1):129-132.

[PDF-532.96 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Pournaras, Spyros ; Ntokou, Eleni ; Zarkotou, Olympia ; Ranellou, Kyriaki ; Themeli-Digalaki, Katerina ; ... More +

Pournaras, Spyros ; Ntokou, Eleni ; Zarkotou, Olympia ; Ranellou, Kyriaki ; Themeli-Digalaki, Katerina ; Stathopoulos, Constantinos ; Tsakris, Athanassios Less -
Description:

We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.
Subjects:

[+]

Acetamides Adult Aged Amino Acid Substitution Anti-Bacterial Agents Dispatch DNA, Bacterial Drug Resistance, Bacterial Female Humans Male Microbial Sensitivity Tests Middle Aged Oxazolidinones Point Mutation Ribosomal Proteins RNA, Ribosomal, 23S Serotyping Staphylococcal Infections
Source:

Emerg Infect Dis. 19(1):129-132.
Document Type:

Journal Article
Place as Subject:

Greece
Location:

Europe
Volume:

19
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:eaed4c99e26cb8350ce4b7e44b3cfbf8db3ba35aa7f5647926b51da69d69b785
Download URL:

https://stacks.cdc.gov/view/cdc/18638/cdc_18638_DS1.pdf
File Type:

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