Lung Cancer Incidence in Never Smokers

Details

• Personal Author:
  Chang ET ; Clarke CA ; Feskanich D ; Gomez SL ; Gould MK ; Holmberg L ; Keegan TH ; Kolonel LN ; Wakelee HA ; West DW ; Yong LC
• Description:
  Purpose: Lung cancer is a leading cause of cancer death worldwide. Although smoking remains the predominant cause of lung cancer, lung cancer in never smokers is an increasingly prominent public health issue. However, data on this topic, particularly lung cancer incidence rates in never smokers, are limited. Methods We reviewed the existing literature on lung cancer incidence and mortality rates among never smokers and present new data regarding rates in never smokers from the following large, prospective cohorts: Nurses' Health Study; Health Professionals Follow-Up Study; California Teachers Study; Multiethnic Cohort Study; Swedish Lung Cancer Register in the Uppsala/Orebro region; and First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study. Results: Truncated age-adjusted incidence rates of lung cancer among never smokers age 40 to 79 years in these six cohorts ranged from 14.4 to 20.8 per 100,000 person-years in women and 4.8 to 13.7 per 100,000 person-years in men, supporting earlier observations that women are more likely than men to have non-smoking-associated lung cancer. The distinct biology of lung cancer in never smokers is apparent in differential responses to epidermal growth factor receptor inhibitors and an increased prevalence of adenocarcinoma histology in never smokers. Conclusion: Lung cancer in never smokers is an important public health issue, and further exploration of its incidence patterns, etiology, and biology is needed. [Description provided by NIOSH]
• Subjects:
  Carcinogens Epidemiology Genetics Lung Lung Diseases Mortality Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Sex Characteristics

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• Keywords:
  Cancer-rates Carcinogenicity Genetic-factors Lung-cancer Lung-disease Lung-disorders Mortality-data Occupational-exposure Pulmonary-cancer Pulmonary-disorders Respiratory-system-disorders Risk-analysis Risk-factors Sex-factors

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• ISSN:
  0732-183X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Hawaii ; Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  472-478
• Volume:
  25
• Issue:
  5
• NIOSHTIC Number:
  nn:20031669
• Citation:
  J Clin Oncol 2007 Feb; 25(5):472-478
• Contact Point Address:
  HA Wakelee, Stanford Clin Canc Ctr, Div Med Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305
• Email:
  hwakelee@stanford.edu
• CAS Registry Number:
  Berkelium (CAS RN 7440-40-6)
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Clinical Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3f9b3eed15130641be880f63525de33c2eab766d96d4217299c7da335c96307fea59fcb60f63e549ec53613daffbb5cb1e8b02943b8485b5cca1886948eaa820
• Download URL:
  https://stacks.cdc.gov/view/cdc/185881/cdc_185881_DS1.pdf
• File Type:
  [PDF - 84.74 KB ]