Re: lung cancer incidence among patients with beryllium disease

Details

• Personal Author:
  Eisenbud M ; Steenland, Kyle ; Ward E
• Description:
  In this letter to the editor and a reply, earlier reports of an excess of lung cancer occurring among patients with beryllium (7440406) disease were considered. Of the 689 patients in the study, 28 died of lung cancer that developed after entry into the registry. Of the 689 patients, 235 were suffering from acute beryllium disease and 17 of these died of lung cancer. All 17 of these patients had a history of employment at a facility in Lorain, Ohio, where the exposure levels were high. The Lorain facility had employed 61% of all patients who had acute beryllium disease reported to the registry. There may have been a confounding factor in the Lorain cohort which may have been cigarette smoking or another carcinogen. Exposure to workers has been reduced more than 100 fold below those that existed when the Lorain facility was in operation. In the response, the authors of the original study indicated that the sparse numbers make it difficult to draw any conclusions about lung cancer risk at Lorain versus the other facilities. The increased risk of lung cancer was not confined to the workers at the Lorain facility. Data were not adequate to develop lung cancer risk estimates by quantitative level of exposure. [Description provided by NIOSH]
• Subjects:
  Carcinogens Epidemiology Lung Lung Diseases Mortality Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Cancer-rates Lung-cancer Mortality-data NIOSH-Author Occupational-exposure Respiratory-system-disorders Risk-analysis Risk-factors
• ISSN:
  0027-8874
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  85
• Issue:
  20
• NIOSHTIC Number:
  nn:00218486
• Citation:
  J Natl Cancer Inst 1993 Oct; 85(20):1697-1699
• CAS Registry Number:
  Berkelium (CAS RN 7440-40-6)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  False
• Source Full Name:
  Journal of the National Cancer Institute
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2ed05409bb41f87bdce3bf9e91bb9086b024becc0d13237665c8cad0020f4d3df76e81910c6e91bec041c9248ed2f1eee0481296fff7c8e057956b383c8bd80a
• Download URL:
  https://stacks.cdc.gov/view/cdc/205458/cdc_205458_DS1.pdf
• File Type:
  [PDF - 304.87 KB ]