Unsuspected Dengue and Acute Febrile Illness in Rural and Semi-Urban Southern Sri Lanka

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Reller, Megan E. ; Bodinayake, Champika ; Nagahawatte, Ajith ; Devasiri, Vasantha ; Kodikara-Arachichi, Wasantha ; Strouse, John J. ; Broadwater, Anne ; Østbye, Truls ; de Silva, Aravinda ; Woods, Christopher W.
• Description:
  Dengue virus (DENV), a globally emerging cause of undifferentiated fever, has been documented in the heavily urbanized western coast of Sri Lanka since the 1960s. New areas of Sri Lanka are now being affected, and the reported number and severity of cases have increased. To study emerging DENV in southern Sri Lanka, we obtained epidemiologic and clinical data and acute- and convalescent-phase serum samples from patients >2 years old with febrile illness. We tested paired serum samples for DENV IgG and IgM and serotyped virus by using isolation and reverse transcription PCR. We identified acute DENV infection (serotypes 2, 3, and 4) in 54 (6.3%) of 859 patients. Only 14% of patients had clinically suspected dengue; however, 54% had serologically confirmed acute or past DENV infection. DENV is a major and largely unrecognized cause of fever in southern Sri Lanka, especially in young adults.
• Subjects:
  Adolescent Adult Aedes Aegypti Aged Antibodies, Viral Child Child, Preschool Cohort Studies Dengue Dengue Virus Female Fever Humans Male Middle Aged Molecular Typing Rural Population Serotyping Suburban Population Young Adult

  More +
• Source:
  Emerg Infect Dis. 18(2):256-263.
• Document Type:
  Journal Article
• Place as Subject:
  Sri Lanka
• Volume:
  18
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1b113dddd1827d4dea5fcbea45f8dc59668ba975b042e9fedc7b7c47ecbc3854
• Download URL:
  https://stacks.cdc.gov/view/cdc/18583/cdc_18583_DS1.pdf
• File Type:
  [PDF - 193.68 KB ]