Occupational Exposures and Risk of Systemic Lupus Erythematosus: A Review of the Evidence and Exposure Assessment Methods in Population- and Clinic-Based Studies

Details

• Personal Author:
  Cooper GS ; Parks CG
• Description:
  Epidemiologic and experimental research suggests a potential role of occupational exposures in the development of systemic lupus erythematosus (SLE). A plausible association has been identified in studies of occupational silica exposure and SLE, complemented by experimental studies in lupus-prone mice exploring potential mechanisms related to apoptosis and immune dysregulation. Experimental studies of the solvent trichloroethylene in lupus-prone mice provide evidence of effects on immune function, including increased production of autoantibodies and activation of CD4+ T cells. However, few studies of occupational solvent exposure and SLE have been conducted, and those that are available show little evidence of an association. There is some suggestion from the available studies of the potential influence of pesticides on SLE, but as with solvents, the specific type of pesticides that may be implicated is not known. Our understanding of the role of occupational exposures in SLE could be advanced by the development of larger, multisite or parallel studies that utilize similar questionnaire and exposure evaluation methods. Multiple studies using comparable exposure measures are needed to provide sufficient sample size for examining gene-environment interactions. We provide a general overview of data requirements and methods available for the assessment and evaluation of occupational exposures in clinical and population-based studies of SLE. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Animals Environmental Monitoring Epidemiology Insecticides Laboratories Occupational Health Risk Assessment Risk Factors Safety Silicon Dioxide Skin Skin Diseases Solvents

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• Keywords:
  Animal-studies Clinical-pathology Clinical-symptoms Clinical-tests Exposure-assessment Laboratory-animals Pesticides Risk-factors Silica-dusts Silicates Skin-disorders Skin-lesions

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• ISSN:
  0961-2033
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  11
• NIOSHTIC Number:
  nn:20031488
• Citation:
  Lupus 2006 Jan; 15(11):728-736
• Contact Point Address:
  CG Parks, Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  cop8@cdc.gov
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Lupus
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0c31ea281238a79262a40f26ec450ecfdedcd3eaf4565190875008cf3c643558d6e818de79020e99e8d974274301e39694d86e304a2c54bc3c7bfb2194c964ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/185763/cdc_185763_DS1.pdf
• File Type:
  [PDF - 160.24 KB ]