Occupational and Environmental Exposures as Risk Factors for Systemic Lupus Erythematosus

Details

• Personal Author:
  Cooper GS ; Parks CG
• Description:
  Although genetic susceptibility plays a strong role in the etiology of systemic lupus erythematosus (SLE), recent research has provided new evidence of the potential influence of environmental factors in the risk for this disease. This paper describes epidemiologic and experimental research pertaining to occupational and environmental sources of exposure to respirable crystalline silica, solvents and pesticides, and two "lifestyle" factors (smoking and hair dye use). As has been seen with other systemic autoimmune diseases (eg, systemic sclerosis and rheumatoid arthritis), a series of epidemiologic studies, using different designs in different settings, have demonstrated relatively strong and consistent associations between occupational silica exposure and SLE. The type and quality of exposure assessment is an important consideration in evaluating these studies. Recent experimental studies examined the effect of trichloroethylene exposure in MRL+/+ mice, but to date there have been few epidemiologic studies of solvents and SLE. There are numerous avenues with respect to environmental factors in SLE that need additional research. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Animals Environmental Exposure Environmental Health Environmental Monitoring Epidemiology Insecticides Laboratories Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Silicon Dioxide Solvents

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• Keywords:
  Animal-studies Diseases Environmental-exposure Environmental-factors Etiology Exposure-assessment Laboratory-animals Occupational-exposure Pesticides Risk-factors Silica-dusts Silicates

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• ISSN:
  1523-3774
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  367-374
• Volume:
  6
• Issue:
  5
• NIOSHTIC Number:
  nn:20029013
• Citation:
  Curr Rheumatol Rep 2004 Oct; 6(5):367-374
• Contact Point Address:
  Epidemiology Branch MDA3-05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
• Email:
  cooper1@niehs.nih.gov
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Current Rheumatology Reports
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:18af74f0286bf03b10d15a73f9ebd673f6afe1c8ee695a1b92b9c6db80431497b640af6e0548a11ef11e64c0396359c2f562511c09a018502166056efa57ee4a
• Download URL:
  https://stacks.cdc.gov/view/cdc/190090/cdc_190090_DS1.pdf
• File Type:
  [PDF - 365.39 KB ]