Volatile metabolites in sera of normal and diabetic patients.

Details

• Personal Author:
  Bafus DA ; Brazell R ; Poole CF ; Spencer PS ; Zlatkis A
• Description:
  The profiles of volatile metabolites in serum samples obtained from normal individuals and diabetic patients with symmetrical distal polyneuropathy were assessed in relation to the production of endogenous neurotoxic diketones. Serum samples extracted with 2- chloropropane were analyzed by gas chromatography mess spectrometry using a transevaporator sampling procedure. Chromatograms from normal samples showed a consistent pattern of peaks. Varying chromatographic patterns were obtained from diabetic patients depending upon the degree of neuropathy and the drug treatment regimen. The chromatograms of patients receiving insulin were similar to the normal pattern, whereas the chromatograms of chronic diabetics receiving no therapy were showed significant differences from normal. No correlation was found between the severity of the neuropathy and the concentrations of specific ketones. The results were discussed in relation to the oxidation of 2-hexanone (591786) and 3-heptanone (106354) and their metabolites to form gamma diketones. [Description provided by NIOSH]
• Subjects:
  Chemistry Chemistry, Analytic Chromatography Energy Metabolism Nervous System Nervous System Diseases Occupational Health Polycyclic Aromatic Hydrocarbons Safety Solvents
• Keywords:
  Analytical-chemistry Aromatic-hydrocarbons Chromatographic-analysis Metabolic-disorders Neurological-diseases Neurotoxic-effects NIOSH-Grant NIOSH-Publication Organic-solvents
• ISSN:
  0021-9673
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  137-145
• Volume:
  182
• Issue:
  2
• NIOSHTIC Number:
  nn:00185563
• Citation:
  J Chromatogr 1980 May; 182(2):137-145
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  2-Hexanone (CAS RN 591-78-6) ; 3-Heptanone (CAS RN 106-35-4)
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Journal of Chromatography
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dbdf46827df2333847b04144960638f957a6fbb3f13d092e5d9d81d0548ac6b6bf8537ac675e3684bb6eb59e9f732ae4e02747381ddbcdae9b7abae64b488e7a
• Download URL:
  https://stacks.cdc.gov/view/cdc/185712/cdc_185712_DS1.pdf
• File Type:
  [PDF - 571.37 KB ]