Occupational risk factors and Alzheimer's disease: a case-control study.

Details

• Personal Author:
  Baker EL Jr. ; Seltzer B ; Shalat SL
• Description:
  A case/control study was made to evaluate occupational exposure to solvents or lead (7439921) and resulting dementia, clinically indistinguishable from dementia of the Alzheimer's type. Cases were obtained from a veterans hospital in Bedford, Massachusetts. All were male patients diagnosed with Alzheimer's type dementia (DAT). These cases were included solely on the basis of clinical presentation. Direct questions and a semi open ended questionnaire were used to solicit information on previous occupational exposure to organic solvents and/or lead. Questions concerned the subject's work in one or more of 18 industrial categories along with specifying job titles and dates of employment in those industries. DAT patients had a slightly higher educational level than comparison subjects and had held slightly more jobs. Those with a clear and significant workplace exposure to organic solvents suffered from no appreciable excess risk of DAT. To control for a possible response bias, an evaluation was also made based upon the occupations listed in the Massachusetts townbooks of registered voters. For a total of 54 cases and 231 matched comparisons, an analysis indicated a slight deficit of DAT patients among those who had been employed in occupations involving a clear and significant exposure to organic solvents. Possible explanations for these results were discussed. [Description provided by NIOSH]
• Subjects:
  Epidemiology Inhalation Exposure Lead Mental Disorders Mental Health Nervous System Nervous System Diseases Occupational Health Safety Solvents
• Keywords:
  Inhalants JOCMA7 Lead-compounds Mental-disorders Nervous-system-disorders Neurotoxic-effects NIOSH-Author NIOSH-Grant NIOSH-Publication Solvent-vapors
• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  30
• Issue:
  12
• NIOSHTIC Number:
  nn:00185200
• Citation:
  J Occup Med 1988 Dec; 30(12):934-936
• Contact Point Address:
  Physiology Harvard School of Public Hlth 665 Huntington Ave Boston, Mass 02115
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1989
• NORA Priority Area:
  Neurotoxic Effects
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19830701
• Source Full Name:
  Journal of Occupational Medicine
• End Date:
  19860531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:80f78d35e785247f54125154b92003757eadf9e5c92dcac9772e7946613bddd6930bb38e23de4507600339d4de6a9d109dee71d3ff8b18d6b8334c429ba2618a
• Download URL:
  https://stacks.cdc.gov/view/cdc/185698/cdc_185698_DS1.pdf
• File Type:
  [PDF - 359.10 KB ]