The synergism of n-hexane-induced neurotoxicity by methyl isobutyl ketone following subchronic (90 days) inhalation in hens: induction of hepatic microsomal cytochrome P-450

Details

• Personal Author:
  Abou-Donia MB ; Campbell G ; Lapadula DM ; Timmons PR ; Abou-Donia MB ; Campbell G ; Lapadula DM ; Timmons PR
• Description:
  The effect of methyl-isobutyl-ketone (108101) (MiBK) on the neurotoxicity of n-hexane (110543) was studied as an example of joint action of aliphatic solvents. A group of leghorn-hens was exposed to vapors containing 1000 parts per million (ppm) n-hexane and another group was exposed to 1000ppm MiBK each for 90 days. Four groups were exposed simultaneously to 1000ppm n-hexane in combination with 100, 250, 500, or 1000ppm MiBK. Continuous inhalation of 1000 MiBK caused leg weakness in hens after approximately 44 days. Hens exposed to 1000ppm n-hexane demonstrated mild ataxia. Exposure to mixed vapors caused ataxia after a latent period of 10 to 29 days, depending on MiBK concentration. All hens exposed to 1000ppm n-hexane and 250, 500 or 1000ppm MiBK developed all stages of ataxia and progressed to paralysis. Hens continuously exposed to 1000/100ppm n-hexane/MiBK demonstrated severe ataxia and their clinical condition did not change during the observation period. The spinal cord of one hen exposed to 1000ppm n-hexane demonstrated equivocal histologic changes in the lumbar region. The authors conclude that the nonneurotoxic chemical MiBK synergized the neurotoxic action of the weak neurotoxicant n-hexane as the coneurotoxicity coefficient for joint exposure was more than two times the additive effect of each treatment alone. [Description provided by NIOSH]
• Subjects:
  Alkanes Butanones Laboratories Nervous System Nervous System Diseases Occupational Health Respiratory System Safety Solvents
• Keywords:
  Inhalation-studies Ketones Laboratory-animals Nervous-system-disorders Neurotoxic-effects NIOSH-Grant NIOSH-Publication Organic-solvents Solvent-vapors
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-16
• Volume:
  81
• Issue:
  1
• NIOSHTIC Number:
  nn:00214014
• Citation:
  Toxicol Appl Pharmacol 1985 Oct; 81(1):1-16
• Contact Point Address:
  Pharmacology Duke University Department of Pharmacology Durham, N C 27710
• CAS Registry Number:
  Hexane (CAS RN 110-54-3) ; Methyl isobutyl ketone (CAS RN 108-10-1) ; Hexane (CAS RN 110-54-3) ; Methyl isobutyl ketone (CAS RN 108-10-1)
• Federal Fiscal Year:
  1986
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects ; Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Duke University, Durham, North Carolina
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19980331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19724feb2c7fe59e5a0c7259cc5fb0f8b77c06ad19cd02692530cb4d96c9f148d7fa22f0ea93ff3b4f1610b0d48290e993e1087e9639b5e02b4bfb414dd5b80c
• Download URL:
  https://stacks.cdc.gov/view/cdc/205784/cdc_205784_DS1.pdf
• File Type:
  [PDF - 1.05 MB ]