Screening of priority chemicals for reproductive hazards. Monoethanolamine (CAS No. 141-43-5), diethanolamine (CAS No. 111-42- 2), triethanolamine (CAS No. 102-71-6).

Details

• Description:
  Monoethanolamine (141435), diethanolamine (111422), and triethanolamine (102716) were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Phase one and two of the tests involved the determination of the median lethal dose for these chemicals and the third phase involved the reproductive effects study. In the first phase doses were administered by gavage on 5 consecutive days. In the second and third phases the doses were given on gestation days six through 15. Monoethanolamine, administered at 850mg/kg/day, was toxic to pregnant animals causing a 16 percent mortality. Monoethanolamine reduce the number of viable litters but did not affect litter size, the percent survival of the pups, the birth weight of the pups or the weight gained by the pups. Diethanolamine, administered at 1125mg/kg/day, caused no change in maternal mortality, number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups. Triethanolamine, administered at 1125mg/kg/day, did not affect maternal mortality, the number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups. [Description provided by NIOSH]
• Subjects:
  Fetus Laboratories Lubricants Occupational Health Safety Teratogenesis Urogenital Diseases Urogenital System
• Keywords:
  Contract-200-84-2735 Embryotoxicity Ethanolamines Laboratory-animals NIOSH-Contract Reproductive-effects Reproductive-hazards
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-61
• NIOSHTIC Number:
  nn:00183527
• NTIS Accession Number:
  PB89-139067
• Citation:
  Environmental Health Research and Testing, Inc., Cincinnati, Ohio 1987 Apr; :1-61
• CAS Registry Number:
  Diethanolamine (CAS RN 111-42-2) ; Ethanolamine (CAS RN 141-43-5) ; Triethanolamine (CAS RN 102-71-6)
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  False
• Source Full Name:
  Environmental Health Research and Testing, Inc., Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2423026a378c2267db3ddda1360c19a5d9acb8171889be051c63560f6df64d829e265b519b7faa52125329eae4e81e3ae5ba466592554fbf87babf5fc2462e08
• Download URL:
  https://stacks.cdc.gov/view/cdc/185665/cdc_185665_DS1.pdf
• File Type:
  [PDF - 1.33 MB ]