Screening of priority chemicals for reproductive hazards. Triorthocresyl phosphate (CAS No.: 78-30-8), 4,4'-thiobis (6-t-butyl-m-cresol) (CAS No.: 96-69-5), 13-cis-retinoic acid (CAS No.: 4759-48-2).

Details

• Description:
  Triorthocresyl-phosphate (78308), 4,4'-thiobis(6-t-butyl-m-cresol) (96695), and 13-cis-retinoic-acid (4759482) were screened for their potential to cause adverse reproductive effects using a postnatal mouse screening test. In the first two phases of the study experiments were designed to determine the appropriate dose levels for the different compounds. In the third phase the reproductive effects were studied. Female CD-1-mice were dosed by gavage on 5 consecutive days for phase one and on gestation days six through 15 for the second and third phases of the study. The predicted median lethal dose for triorthocresyl-phosphate was 515mg/kg/day and for 4,4'-thiobis it was 485mg/kg/day. The 13-cis-retinoic-acid (4759482) was administered at 85mg/kg/day, due to the limited amount of chemical available. All animals received a constant volume of 10 milliliters/kilogram/day. Triorthocresyl-phosphate cause an increased maternal mortality and a decreased number of viable litters but had no effect on litter size or birth weight gain. 4,4'- Thiobis(6-t-butyl-m-cresol) caused increases in maternal mortality and a decreased percent of pup survival while not affecting the number of viable litters, the litter size, birth weight or weight gain of the pups. 13-cis-Retinoic-acid had no effect on maternal mortality, the number of viable litters, litter size, or pup birth weight. [Description provided by NIOSH]
• Subjects:
  Fetus Hazardous Substances Laboratories Occupational Health Phosphoric Acids Safety Teratogenesis Urogenital Diseases Urogenital System
• Keywords:
  Contract-200-84-2735 Embryotoxicity Laboratory-animals NIOSH-Contract Phosphates Reproductive-effects Reproductive-hazards Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-64
• NIOSHTIC Number:
  nn:00183524
• NTIS Accession Number:
  PB89-139075
• Citation:
  Environmental Health Research and Testing, Inc., Cincinnati, Ohio 1987 Apr; :1-64
• CAS Registry Number:
  4,4′-Thiobis(3-methyl-6-tert-butylphenol) (CAS RN 96-69-5) ; Isotretinoin (CAS RN 4759-48-2) ; o-Cresyl phosphate (CAS RN 78-30-8)
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  False
• Source Full Name:
  Environmental Health Research and Testing, Inc., Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a3742629b242541fc79d25bec2cf0c64b89673d12d176b8bbd3497446cf2ffcd6dd0551c244d6b95a7033704058a6134be7026577e10c85ad296374e52953a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/185663/cdc_185663_DS1.pdf
• File Type:
  [PDF - 1.38 MB ]