Reproductive toxicity of 2,4-dinitrotoluene in the rat.

Details

• Personal Author:
  Bloch E ; Gatz M ; Gondos B ; Thysen B ; Varma SK
• Description:
  The toxic reproductive effects of the chemosterilant 2,4- dinitrotoluene (121142) (DNT) were evaluated in the rat. Male Sprague-Dawley-rats were fed 0, 0.1, or 0.2 percent DNT for a period of 3 weeks. Blood samples were collected for assessment of luteinizing-hormone (LH), follicle-stimulating-hormone (FSH), and testosterone levels prior to sacrifice. Testes and epididymides were then removed for ultrastructural evaluation and sperm reserve counts. DNT exposure at a concentration of 0.2 percent was associated with a marked change in Sertoli cell morphology. No Leydig cell changes were detected. Alterations induced by DNT included varying sized vesicles associated with swollen mitochondria and distended endoplasmic reticulum, increased levels of circulating LH and FSH, reduced weights of epididymides, and decreased epididymal sperm reserves (63 percent reduction in animals treated with 0.2 percent DNT). Testosterone levels were unaffected by DNT. Sperm concentrations and serum hormone levels were not significantly affected by 0.1 percent DNT. The authors conclude that DNT can induce testicular injury, directly or indirectly disturb pituitary function, and exert a toxic effect at late stages of spermatogenesis. The Sertoli cell may be a locus of DNT induced inhibition of spermatogenesis and altered testicular/pituitary endocrine function. [Description provided by NIOSH]
• Subjects:
  Endocrine System Hazardous Substances Laboratories Nitrogen Compounds Occupational Health Safety Toluene Urogenital Diseases Urogenital System
• Keywords:
  Cell-damage Endocrine-system Gonadotropic-hormones In-vivo-studies Laboratory-animals NIOSH-Grant NIOSH-Publication Nitro-compounds Reproductive-effects Reproductive-hazards Toluenes Toxic-effects

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; New York ; OSHA Region 2 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  466-472
• Volume:
  94
• Issue:
  3
• NIOSHTIC Number:
  nn:00182359
• Citation:
  Toxicol Appl Pharmacol 1988 Jul; 94(3):466-472
• Contact Point Address:
  Laboratory Medicine Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  2,4-Dinitrotoluene (CAS RN 121-14-2)
• Federal Fiscal Year:
  1988
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19821201
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19901130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b0dac6109918b563b8d1b4616bc6c3f22a86a905e3002c5313a910f722ebcd1a0ca8416dd2473ae85cd39f7dad87dc1416092629cc27f507d6ac1ec5abf117f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/185634/cdc_185634_DS1.pdf
• File Type:
  [PDF - 496.65 KB ]