The effects of tris(2,3-dibromopropyl)phosphate on the reproductive system of male rats.

Details

• Personal Author:
  Cochran RC ; Wiedow MA
• Description:
  Adult male Sprague-Dawley-rats were studied to determine the amounts of tris(2,3-dibromopropyl)phosphate (126727) (TRIS) required to produce significant effects on spermatogenesis, to examine other organs of the male reproductive tract for effects of TRIS, and to examine possible mechanisms for TRIS reproductive toxicity. A dose dependent decrease in body weight was observed after injection of vesicles, and epididymis decreased significantly in a dose dependent manner. Prostate weight also decreased significantly. Histological changes were noted in some seminferous tubules. In a dose dependent manner, sperm production by the testes was reduced, as well as sperm content of the epididymal tail. The percentage of motile sperm and the motility index were also affected. Serum testosterone levels and the in-vitro testicular capacity for testosterone secretion were not affected. Results suggested that TRIS does not affect reproductive endocrinology. The authors suggest that shrinkage of the testes resulted from diminished sperm production. [Description provided by NIOSH]
• Subjects:
  Endocrine System Flame Retardants Hazardous Substances Laboratories Microbiology Occupational Health Phosphoric Acids Safety Urogenital Diseases
• Keywords:
  Endocrine-system Flame-retardants Histopathology Hormones In-vivo-studies Laboratory-animals Microscopic-analysis NIOSH-Grant NIOSH-Publication Phosphates Reproductive-system-disorders Toxic-effects

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• ISSN:
  0730-0913
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  153-160
• Volume:
  5
• Issue:
  2
• NIOSHTIC Number:
  nn:00165205
• Citation:
  J Amer Coll Toxicol 1986 Mar; 5(2):153-160
• Contact Point Address:
  R. C. Cochran, Chesapeake Bay Institute, The Johns Hopkins Universi'y. Shady Side, Maryland
• CAS Registry Number:
  Tris (CAS RN 126-72-7)
• Federal Fiscal Year:
  1986
• Performing Organization:
  Johns Hopkins University 4800 Atwell Road Shady Side, MD 20764
• Peer Reviewed:
  True
• Start Date:
  19830701
• Source Full Name:
  Journal of the American College of Toxicology
• End Date:
  19840130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5ce609adf6f616e042ca43c88580bb228c40ecb79be91db4a8ee55ce830bca71b60598556ce6996030c134d49bb2ddafb5677c12adc911c34d26fe88d7703536
• Download URL:
  https://stacks.cdc.gov/view/cdc/185061/cdc_185061_DS1.pdf
• File Type:
  [PDF - 603.10 KB ]