Relative potency of four ethylene glycol ethers for induction of paw malformations in the CD-1 mouse.

Details

• Personal Author:
  Eisenmann CJ ; Hardin, Bryan D.
• Description:
  The pattern of paw malformations induced in CD-1-mouse fetuses by single maternal doses of dimethyl substituted ethylene glycol ethers was compared to that produced by ethylene-glycol-monomethyl-ether (109864) (EGME). Fetal paw malformations were quantitated following single equimolar doses of EGME, ethylene-glycol-dimethyl-ether (110714) (EGDME), diethylene-glycol-dimethyl-ether (111966) (DEGDME), and triethylene-glycol-dimethyl-ether (112492) (TEGDME) administered on day 11 of pregnancy. Fetuses were collected on day 18 of pregnancy and examined for paw malformations. These compounds were not toxic to the maternal rats at the concentrations utilized and did not affect uterine survival significantly. While only EGDME caused significant reductions in fetal weight, each compound except TEGDME produced a significant number of fetal paw malformations. Such malformations occurred in 87.5 percent, 86.7 percent, and 77.8 percent of litters from rats treated with EGME, EGDME, and DEGDME, respectively. Syndactyly was the most frequently encountered malformation observed, occurring more frequently in hindpaws than in forepaws. Other malformations encountered included oligodactyly and reduced digit size. The authors conclude that each of the active compounds is metabolized to a common teratogen, methoxyacetic-acid (625456). [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Ether Glycols Hazardous Substances Laboratories Occupational Health Safety Teratogenesis Toxicology Urogenital System
• Keywords:
  Comparative-toxicology Developmental-disorders Embryotoxicity Ethers In-vivo-studies Laboratory-animals Metabolites NIOSH-Author Teratology Toxic-effects Transplacental-exposure

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• ISSN:
  0040-3709
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  321-328
• Volume:
  35
• Issue:
  3
• NIOSHTIC Number:
  nn:00172876
• Citation:
  Teratology 1987 Jun; 35(3):321-328
• CAS Registry Number:
  1,2-Dimethoxyethane (CAS RN 110-71-4) ; 2-Methoxyethanol (CAS RN 109-86-4) ; Diglyme (CAS RN 111-96-6) ; Methoxyacetic acid (CAS RN 625-45-6) ; Triglyme (CAS RN 112-49-2)
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  True
• Source Full Name:
  Teratology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:12b7c61abb6cc046757718383cfa9eb4325c3a5d60249a89c09822b8a367f7de05f4a2e45ebb1850c7daaa654dae28845549000b698855add137928b7c44f98e
• Download URL:
  https://stacks.cdc.gov/view/cdc/185276/cdc_185276_DS1.pdf
• File Type:
  [PDF - 528.55 KB ]