Results of testing fifteen glycol ethers in a short-term in vivo reproductive toxicity assay.

Details

• Personal Author:
  Booth G ; Hardin, Bryan D. ; Hazelden K ; Niemeier RW ; Piccirillo V ; Schuler RL ; Smith K
• Description:
  A screening bioassay of the reproductive effects of glycol ethers was conducted in mice. Pregnant CD-1-mice were administered 15 glycol ethers orally on days seven through 14 of gestation at concentrations ranging up to 11270mg/kg. The potential of the compounds for causing adverse reproductive effects was evaluated by determining pup survival in-utero, pup perinatal survival, and postnatal survival (number of live pups per litter, number of dead pups per litter, and pup survival up to 2.5 days of age), and pup weights at birth and 2.5 days of age. Maternal mortality was recorded. Maternal mortality ranged up to 41 percent, the largest number of deaths occurring after treatment with diethylene-glycol- dimethyl-ether (111966). Mice treated with ethylene-glycol- monomethyl-ether (109864) (EGME), ethylene-glycol-monoethyl-ether (110805) (EGEE), ethylene-glycol-dimethyl-ether (110714), and triethylene-glycol-dimethyl-ether (112492) produced no litters. Mice treated with ethylene-glycol (107211), ethylene-glycol- monobutyl-ether (111762), ethylene-glycol-diethyl-ether (629141) (EGdiEE), and diethylene-glycol-monomethyl-ether (111773) (diEGME) showed significant reductions in viable litters. Ethylene-glycol and EGdiEE reduced the number of live pups per litter, and pup birth weight and weight gain. diEGME significantly reduced the number of live pups per litter and pup survival. Diethylene-glycol-diethyl- ether (112367) significantly increased the number of dead pups per litter and reduced pup birth weights. Diethylene-glycol-dibutyl- ether (112732) increased the number of dead pups per litter. Diethylene-glycol (111466) reduced pup weight gain. Triethylene- glycol (112276) and diethylene-glycol-monoethyl-ether (111900) reduced mean pup birth weights. The authors note that, on the basis of their results, they cannot definitely label a given compound as safe or unsafe and that the compounds should be tested further, especially EGME, EGEE, and EGdiME which are known to be teratogenic in other studies. [Description provided by NIOSH]
• Subjects:
  Biological Assay Glycols Hazardous Substances Laboratories Occupational Health Safety Urogenital System
• Keywords:
  Bioassays Embryotoxicity In-vivo-studies Laboratory-animals NIOSH-Author Organic-chemicals Reproductive-effects Toxic-effects Transplacental-exposure
• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  141-146
• Volume:
  57
• NIOSHTIC Number:
  nn:00168042
• Citation:
  Environ Health Perspect 1984; 57:141-146
• CAS Registry Number:
  1,2-Dimethoxyethane (CAS RN 110-71-4) ; 2-Butoxyethanol (CAS RN 111-76-2) ; 2-Methoxyethanol (CAS RN 109-86-4) ; Diethylene glycol (CAS RN 111-46-6) ; Diethylene glycol dibutyl ether (CAS RN 112-73-2) ; Diethylene glycol diethyl ether (CAS RN 112-36-7) ; Diethylene glycol monoethyl ether (CAS RN 111-90-0) ; Diethylene glycol monomethyl ether (CAS RN 111-77-3) ; Diglyme (CAS RN 111-96-6) ; Ethylene glycol (CAS RN 107-21-1) ; Ethylene glycol diethyl ether (CAS RN 629-14-1) ; Glycol monoethyl ether (CAS RN 110-80-5) ; Triethylene glycol (CAS RN 112-27-6) ; Triglyme (CAS RN 112-49-2)
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24a888a2a9a7b74b045a7cf41a085a4d508f750af03a5afd6976a127b1aef9ee6d24acb459eda6a79cc800824d45f6da3b33e9eb5fac284a2af6b4f8d0e75d49
• Download URL:
  https://stacks.cdc.gov/view/cdc/185166/cdc_185166_DS1.pdf
• File Type:
  [PDF - 1011.46 KB ]