In Utero and Childhood Polybrominated Diphenyl Ether Exposures and Body Mass at Age 7 Years: The CHAMACOS Study

Details

• Journal Article:
  Environmental Health Perspectives
• Personal Author:
  Erkin-Cakmak, Ayca ; Harley, Kim G. ; Chevrier, Jonathan ; Bradman, Asa ; Kogut, Katherine ; Huen, Karen ; Eskenazi, Brenda
• Description:
  Background and Objectives: Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and post-natal exposure to the components of penta-BDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California. Methods: We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index at age 7. Results: Maternal PBDE serum levels during pregnancy were associated with higher body mass index (BMI) z-scores in boys (BMI z-score B(adjusted) = 0.26; 95% CI: -0.19, 0.72) but lower scores in girls (BMI z-score B(adjusted) = -0.41; 95% CI: -0.87, -0.05) at 7 years of age (pinteraction= 0.04). In addition, child's serum BDE-153 concentration (log10), but not other penta-BDE congeners, demonstrated inverse associations with body mass index at age 7 (BMI z-score B(adjusted)= -1.15, 95% CI -1.53, -0.77) but there was no interaction by sex. Conclusions: We estimated sex-specific associations with maternal PBDE levels during pregnancy and body mass index at age 7 with positive associations in boys and negative associations in girls. Children's serum BDE-153 concentrations were inversely associated with body mass index at age 7 with no difference by sex. Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality. [Description provided by NIOSH]
• Subjects:
  Body Weight Children's Health Demography Endocrine System Environmental Health Ether Flame Retardants Occupational Health Pregnancy Race Factors Safety Women

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• Keywords:
  Humans; Children; Ethers; Flame-retardants; Body-weight; Endocrine-system; Prenatal-exposure; Sociological-factors; Demographic-characteristics; Racial-factors; Women; Pregnancy; Statistical-analysis
• Source:
  Environ Health Perspect 2015 Jun; 123(6):636-642
• ISSN:
  0091-6765
• Pubmed ID:
  25738596
• Pubmed Central ID:
  PMC4455588
• Document Type:
  Text
• Funding:
  P01 ES009605/ES/NIEHS NIH HHS/United States ; R01ES015572/ES/NIEHS NIH HHS/United States ; R01OH007400/OH/NIOSH CDC HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7 pdf pages
• Volume:
  123
• Issue:
  6
• NIOSHTIC Number:
  nn:20045853
• Contact Point Address:
  Brenda Eskenazi, Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, 1995 University Ave Suite 265, Berkeley, CA 94720
• Email:
  eskenazi@berkeley.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:c4677161e19a5d5147dd1928afa7b6bc3e54951ba726429ddb00dff28ec3777f47f6f55bed51f779dabacd7bca1b904b8c408a7ab132b1e08c51e9488cf1c3ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/33121/cdc_33121_DS1.pdf
• File Type:
  [PDF - 270.94 KB ]