In Utero and Childhood Polybrominated Diphenyl Ether Exposures and Body Mass at Age 7 Years: The CHAMACOS Study

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Erkin-Cakmak, Ayca ; Harley, Kim G. ; Chevrier, Jonathan ; Bradman, Asa ; Kogut, Katherine ; Huen, Karen ; Eskenazi, Brenda
• Description:
  Background
  
  Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems.
  
  Objective
  
  In this study, we examined whether pre- and postnatal exposure to the components of pentaBDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California.
  
  Methods
  
  We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index (BMI) at age 7 years.
  
  Results
  
  Maternal PBDE serum levels during pregnancy were associated with higher BMI z-scores in boys (BMI z-score βadjusted = 0.26; 95% CI: –0.19, 0.72) but lower scores in girls (BMI z-score βadjusted = –0.41; 95% CI: –0.87, –0.05) at 7 years of age (pinteraction = 0.04). In addition, child’s serum BDE-153 concentration (log10), but not other pentaBDE congeners, demonstrated inverse associations with BMI at age 7 years (BMI z-score βadjusted = –1.15; 95% CI: –1.53, –0.77), but there was no interaction by sex.
  
  Conclusions
  
  We estimated sex-specific associations with maternal PBDE levels during pregnancy and BMI at 7 years of age, finding positive associations in boys and negative associations in girls. Children’s serum BDE-153 concentrations were inversely associated with BMI at 7 years with no difference by sex. Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality.
  
  Citation
  
  Erkin-Cakmak A, Harley KG, Chevrier J, Bradman A, Kogut K, Huen K, Eskenazi B. 2015. In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS Study. Environ Health Perspect 123:636–642; http://dx.doi.org/10.1289/ehp.1408417
  
  
• Subjects:
  Children's Health
• Source:
  Environ Health Perspect. 123(6):636-642.
• Pubmed ID:
  25738596
• Pubmed Central ID:
  PMC4455588
• Document Type:
  Journal Article
• Funding:
  P01 ES009605/ES/NIEHS NIH HHS/United States ; R01ES015572/ES/NIEHS NIH HHS/United States ; R01OH007400/OH/NIOSH CDC HHS/United States
• Volume:
  123
• Issue:
  6
• NIOSHTIC Number:
  nn:20045853
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c4677161e19a5d5147dd1928afa7b6bc3e54951ba726429ddb00dff28ec3777f47f6f55bed51f779dabacd7bca1b904b8c408a7ab132b1e08c51e9488cf1c3ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/33121/cdc_33121_DS1.pdf
• File Type:
  [PDF - 270.94 KB ]