Chronic inhalation of diesel exhaust and coal dust: effect of age and exposure on selected enzyme activities associated with microsomal cytochrome P-450 in rat lung and liver.

Details

• Personal Author:
  Groseclose RD ; Lewis TR ; Marion KJ ; Petersen, Martin R. ; Rabovsky J
• Description:
  The effects of chronic inhalation of diesel exhaust and coal dust on lung and liver microsomal enzyme activities were investigated in 6 week old male Fischer-344-rats. Animals were exposed for 7 hours per day, 5 days per week, for 24 months to: 2 milligrams (mg) diesel exhaust per cubic meter (m3) air; 5mg/m3 coal dust; or 3mg/m3 diesel exhaust and coal dust. Rats were sacrificed at 3, 6, and 24 months after the start of exposure, and microsomes were prepared from lungs and livers. Assays were conducted for: benzo(a)pyrene (BaP)/hydroxylase; 7-ethoxycoumarin deethylase; protein; and cytochrome-P-450. Age related changes in enzyme activities were observed, but they were not altered by the exposures. When the data was adjusted for age, only one difference was observed: lung BaP/hydroxylase activity in rats exposed to both diesel exhaust and coal dust was lower than that in animals exposed to coal dust alone. Neither value, however, differed significantly from the filtered air controls, and no differences were observed in the other lung and liver activities. The authors conclude that exposure of rats to coal dust or diesel exhaust has no effect on selected lung and liver cytochrome-P-450 activities under the conditions of the experiment. [Description provided by NIOSH]
• Subjects:
  Carcinogens Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Cancer Cancer-rates Lung-cancer Lung-cells Lung-fibrosis NIOSH-Author Tumor-inhibition Tumorigenesis Tumorigens Tumors
• ISSN:
  0098-4108
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  5
• NIOSHTIC Number:
  nn:00161427
• Citation:
  J Toxicol Environ Health 1984 Jan; 14(5-6):655-666
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2a4bf5ce5f32c6569e5c9d54b636fa5a245ba25749c117c1fd684cf88807efa26f873be29c3e5c1ee12f4e9ef996bd9b1b49e83515dfbf291b40713a9bc4edc7
• Download URL:
  https://stacks.cdc.gov/view/cdc/184976/cdc_184976_DS1.pdf
• File Type:
  [PDF - 792.53 KB ]