Neoplastic effect of vinyl chloride in mouse lung -- lower doses and short-term exposure.

Details

• Personal Author:
  Suzuki Y
• Description:
  The effect of vinyl-chloride (75014) on the lung was investigated in mice. A total of 220 CD1-mice were divided into groups and exposed to 600, 300, 100, 10, and 1 parts per million (ppm) vinyl-chloride vapor. They were then sacrificed either immediately, 12 weeks after exposure, or 40 weeks after exposure. The organs were subjected to histopathological or electron microscopy procedures. In the 600 and 300ppm groups, alveologenic tumors developed after 12 weeks in 88.8 and 66.6 percent of the animals, respectively. Tumors did not appear at lower exposure concentrations. Multiple tumors occurred at 600ppm. After 41 weeks, pulmonary tumors were induced at all exposure concentrations. There was a clear dose response relationship for instances of alveologenic tumors and a latency period inversely related to dose. Tumors were not encapsulated by connective tissue, and the neoplastic cells were arranged in tubular, papillary, and adenomatous fashion. In rare cases, the tumors occupied the entire lobe of a lung. The neoplastic cells exhibited the ultrastructural characteristics of hyperplastic type 2 cells. The author concludes that alveologenic tumors are induced by vinyl-chloride and that type 2 alveolar cells are the progenitor cells of the tumors. [Description provided by NIOSH]
• Subjects:
  Carcinogens Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Lung Burden Lung Fibrosis Lung Function Lung Irritants Lung Tissue Neoplastic Agents Tumorigenesis Tumorigens Tumors
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-103
• Volume:
  32
• Issue:
  1
• NIOSHTIC Number:
  nn:00145492
• Citation:
  Environ Res 1983 Oct; 32(1):91-103
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1984
• Performing Organization:
  Community Medicine Mount Sinai School of Med Fifth Avenue & 100Th Street New York, N Y 10029
• Peer Reviewed:
  True
• Start Date:
  19761201
• Source Full Name:
  Environmental Research
• End Date:
  19811130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9ba61e7bdc7a80c36f45127387933e1ddf917aa25ee1f61967729d2bf80fc03e812f24b281a1f5f39eb27717c32e97a627636f60afb179a19990df53f752132a
• Download URL:
  https://stacks.cdc.gov/view/cdc/184813/cdc_184813_DS1.pdf
• File Type:
  [PDF - 945.47 KB ]