Developmental toxicity of nine selected compounds following prenatal exposure in the mouse: naphthalene, p-nitrophenol, sodium selenite, dimethyl phthalate, ethylenethiourea, and four glycol ether derivatives.

Details

• Personal Author:
  Booth GM ; Bradshaw WS ; Carter MW ; Hardin, Bryan D. ; Plasterer MR ; Schuler RL
• Description:
  The reproductive toxicity potential of chemicals selected by NIOSH were screened in mice. Female Cd-1-mice had maximum tolerated doses (MTD) determined for ethylene-glycol-dimethyl-ether (110714), (EGdiME), diethylene-glycol-dimethyl-ether (111966) (diEGdiME), triethylene-glycol-dimethyl-ether (112492) (triEGdiME), diethylene- glycol-diethyl-ether (112367) (diEGdiEE), ethylenethiourea (96457) (ETU), sodium-selenite (10102188), dimethyl-phthalate (131113) (DMP), naphthalene (91203) (NAP), and p-nitrophenol (100027) (PNP) by administering several dose concentrations for 8 consecutive days and recording weights, deaths, and necropsies. The dose lethal to 10 percent of the mice was the MTD. The median lethal dose (LD50) was determined. Pregnant mice received eight doses, once daily, of the chemicals based on their MTD. Maternal body weights were recorded. Pups were weighed as a litter and examined individually for gross structural abnormalities. Sodium-selenite, NAP, and PNP had LD50s of 8.4 milligrams per kilogram (mg/kg), 353.6mg/kg, and 625.7mg/kg, respectively, MTD of 7.0mg/kg, 300mg/kg, and 400mg/kg, respectively, and showed no significant effects in reproductive indices. ETU, EGdiME, diEGdiME, and triEGdiME had LD50s of 5985, 2525.8, 2978.7, and 4136.7mg/kg, respectively, and MTD of 600.0, 2000.0, 2000.0, and 3500mg/kg, respectively. These were the only compounds significantly affecting reproductive indices. No EGdiME, diEGdiME, or triEGdiME groups delivered any viable pups. DMP with an LD50 and an MTD of 6281.9mg/kg and 3500.0mg/kg, respectively, had no effect on fetal survival. Sodium-selenite and diEGdiEE moderately, but not significantly, reduced reproductive indices. Maternal lethality was significant in EGdiME, diEGdiME, PNP, and NAP groups. The authors conclude that these chemicals fall into four categories with ETU, diEGdiEE, and triEGdiME in a high priority category for further testing. [Description provided by NIOSH]
• Subjects:
  Animals Hazardous Substances Mortality Nervous System Occupational Health Safety Toxicology
• Keywords:
  Animal-studies Mortality-rates Mortality-surveys Neuropathology NIOSH-Author Physiology Quantitative-analysis Toxic-effects Toxic-materials
• ISSN:
  0098-4108
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  25-38
• Volume:
  15
• Issue:
  1
• NIOSHTIC Number:
  nn:00147550
• Citation:
  J Toxicol Environ Health 1985 Jan; 15(1):25-38
• CAS Registry Number:
  1,2-Dimethoxyethane (CAS RN 110-71-4) ; 4-Nitrophenol (CAS RN 100-02-7) ; Diethylene glycol diethyl ether (CAS RN 112-36-7) ; Diglyme (CAS RN 111-96-6) ; Dimethyl phthalate (CAS RN 131-11-3) ; Ethylenethiourea (CAS RN 96-45-7) ; Naphthalene (CAS RN 91-20-3) ; Sodium selenite (CAS RN 10102-18-8) ; Triglyme (CAS RN 112-49-2)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:726dc7d598cfcfb661304d6e97a227001f835841a4ff75885d4eb38bc69e2fee3f5c54f01e0f3d7ec83ecd19cf3b6a72c1517a2e5f5ca038f17f51a92687215a
• Download URL:
  https://stacks.cdc.gov/view/cdc/184838/cdc_184838_DS1.pdf
• File Type:
  [PDF - 879.11 KB ]