Mutagenicity of the tetramic mycotoxin cyclopiazonic acid.

Details

• Personal Author:
  Simpson JP ; Sorenson WG ; Tucker JD
• Description:
  The mutagenicity of cyclopiazonic-acid (18172333) (CPA) with aflatoxin-B1 (1162658) (AFB1) was investigated by the Ames test using Salmonella-typhimurium TA-98 and TA-100. Mutagenicity was tested by the Ames histidine reversion assay with or without using S9 mixture for metabolic activation. Test concentrations ranged from 0.01 to 1.0 picomoles for CPA and from 0.03 to 30.0 picomoles for AFB1. A possible correlation between concentrations and the number of revertants per plate existed with metabolic activation for TA-98 and TA-100. No such correlation in either strain was evident when S9 mixture was not used in the test. Both CPA and AFB1 produced significant mutagenicity singly and in combination when studied in factorial experiments with TA-98. The mutagenic activity of the two compounds when tested together was additive rather than synergistic. The authors conclude that CPA is commonly produced by organisms such as Aspergillus-flavus and its presence in contaminated grain contributes to the genotoxic hazards of such grain. [Description provided by NIOSH]
• Subjects:
  Agriculture Anti-Bacterial Agents Biological Assay Biopharmaceutics Mutagens Occupational Health Safety Toxicology
• Keywords:
  Agricultural-products Antibiotics Bioassays Comparative-toxicology Dose-response Medical-research NIOSH-Author Pharmaceuticals Quantitative-analysis
• ISSN:
  0099-2240
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  47
• Issue:
  6
• NIOSHTIC Number:
  nn:00146448
• Citation:
  Appl Environ Microbiol 1984 Jun; 47(6):1355-1357
• Contact Point Address:
  W. G. Sorenson, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505
• CAS Registry Number:
  Aflatoxin B1 (CAS RN 1162-65-8) ; Cyclopiazonic acid (CAS RN 181Mestranol (CAS RN 72-33-3))
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  True
• Source Full Name:
  Applied and Environmental Microbiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c5ab6e18e58cf5b727a041e6b1b8802d3d9942c4fbef42eb825b7d336f1848898049bca10e4e2a0b3f2ba881bde3ef3c49fb19d5401f85d5cea002a10cd92166
• Download URL:
  https://stacks.cdc.gov/view/cdc/184825/cdc_184825_DS1.pdf
• File Type:
  [PDF - 535.45 KB ]