Toxicity tests on post office cancelling ink 1882-17.

Details

• Personal Author:
  Gellin GA ; Groth DH ; Key, Marcus M. ; Morrill EE Jr. ; Perone YB ; Wagner WD
• Description:
  The toxicity of an ink used by the US Post Office was studied in humans, rats, rabbits, and guinea-pigs. The composition of the ink was determined. Persons involved in developing the ink were examined. Eye irritation tests were performed on albino-rats. Male rats were used for acute oral toxicity tests. Male albino-rabbits were used for acute dermal toxicity and primary dermal irritation tests. Skin sensitization tests were performed on male albino- guinea-pigs. Patch tests and phototoxicity tests were performed on human volunteers. The composition of the ink in percent by weight was as follows: varnish-120-RDE, 30; carbon-black, 10; diethylene- glycol-monobutyl-ether (112345) (DGME), 50; and isopropanol (67630), 10. The composition of varnish-120-RDE in percent by weight was as follows: 1120-maleic-resin, 40; 70-phthalic-anhydride-soya-alkyd, 15; diethylene-glycol-monomethyl-ether (111773), 25; and DGME, 20. Formulators of the ink showed no signs of adverse skin effects. No positive reactions were observed in the eye irritation tests. No ink related pathology was seen in rats in oral toxicity studies. Acute dermal tests produced negative results. Primary skin irritation and skin sensitization tests were all negative. Patch and phototoxicity tests on humans produced no positive cases. The authors conclude that this ink does not present a health hazard when used for intended applications. [Description provided by NIOSH]
• Subjects:
  Animals Biological Factors Irritants Occupational Health Safety Skin Toxicology
• Keywords:
  Animal-studies Biological-effects Biological-factors Dermatology Physiological-response Skin-sensitivity
• Publisher:
  National Center for Urban and Industrial Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-11
• NIOSHTIC Number:
  nn:00138128
• Citation:
  U.S. Department of Health, Education, and Welfare, Public Health Service, National Center for Urban and Industrial Health, report no. SR-25, 1968 Apr; :1-11
• CAS Registry Number:
  Diethylene glycol monobutyl ether (CAS RN 112-34-5) ; Diethylene glycol monomethyl ether (CAS RN 111-77-3) ; Isopropanol (CAS RN 67-63-0)
• Federal Fiscal Year:
  1968
• Peer Reviewed:
  False
• Source Full Name:
  National Center for Urban and Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:40b0de08c0f9f99e017e5e866068a2edfada1b810756adb7a5d733b51aaaa28450993bab05cede42d1cbfe4830c4c97911931037c364e8d96d6668b97350e9a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/184714/cdc_184714_DS1.pdf
• File Type:
  [PDF - 959.75 KB ]