Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man.

Details

• Personal Author:
  Alarie Y
• Description:
  The median effective doses for respiratory inhibition (RD50) of 26 chemicals are reviewed and evaluated for establishing threshold limit values (TLV) in the workplace. The method of measuring the RD50 is described. RD50s and TLV time weighted averages (TWA) are listed for 26 chemicals including benzoquinone (106514) and styrene (100425), for which values had not previously been unpublished. Log graphs of TLV TWA were compared to 0.03 times the RD50 data. The author concludes that 0.03 RD50 is a useful predictor of sensory irritants that affect man, but does not predict metabolic activation or lung irritation. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Biological Assay Irritants Occupational Health Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Air-contamination Bioassays Exposure-limits NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders Respiratory-irritants Standards
• ISSN:
  0015-6264
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  5
• NIOSHTIC Number:
  nn:00123273
• Citation:
  Food Cosmet Toxicol 1981 Jan; 19(5):623-626
• Contact Point Address:
  Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
• CAS Registry Number:
  Quinone (CAS RN 106-51-4) ; Styrene (CAS RN 100-42-5)
• Federal Fiscal Year:
  1981
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19711001
• Source Full Name:
  Food and Cosmetics Toxicology
• End Date:
  19860531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e320d1b390abbf40c954c4ac6dde8aa029f399feb5cd3fc26f51f9675569ef61a2af8f2b6b9e8b7077359bb36e3939fd2104b6dc5545997934e537a94b715f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/184558/cdc_184558_DS1.pdf
• File Type:
  [PDF - 367.98 KB ]