Comparison of the genetic activity of 5-nitroimidazole derivatives in Escherichia coli, Neurospora crassa, Saccharomyces cerevisiae and Drosophila melanogaster.

Details

• Personal Author:
  Aaron CS ; Kramers PG ; Mohn GR ; Ong TM
• Description:
  The genetic activity of 5-nitroimidazole derivatives was studied. Escherichia-coli (E-coli), Saccharomyces-cerevisiae (S-cerevisiae), Neurospora-crassa (N-crassa), and Drosophila-melanogaster were exposed to metronidazole (443481) and three other 5-nitroimidazole derivatives (compounds 2, 3, 4). Forward and back mutations in the E- coli, forward mutations in N-crassa, mitotic gene conversion in S- cerevisiae, and sex linked recessive lethals in Drosophila were determined. Metronidazole was moderately mutagenic and compounds 2 and 3 were strongly mutagenic in all four test systems. The mutagenicity of 2 and 3 in E-coli was evident even at very low concentrations. Compound 2 had the strongest effect in Drosophila. Compound 4 was nonmutagenic in all tests. The authors conclude that the mutagenic activity of 5-nitroimidazoles differ depending on the test strain. The authors conclude that the differences between the derivatives are probably due to the differences in chemical structure. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Assay Chemistry Genetics Mutagens Nitrogen Compounds Occupational Health Safety Toxicology
• Keywords:
  NIOSH-Author; Nitro-compounds; Comparative-toxicology; Biochemical-tests; Genetic-disorders; Mutagenesis; Chemical-properties; Bioassays
• ISSN:
  0146-4779
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• Issue:
  3
• NIOSHTIC Number:
  nn:00118206
• Citation:
  J Environ Pathol Toxicol 1979 Jan/Feb; 2(3):657-670
• CAS Registry Number:
  Metronidazole (CAS RN 443-48-1)
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology and Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247516/cdc_247516_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]