Chronic cadmium exposure: relation to male reproductive toxicity and subsequent fetal outcome.

Details

• Personal Author:
  Goldsmith M ; Hastings L ; Niewenhuis RJ ; Zenick H
• Description:
  The reproductive effects of chronic cadmium (7440439) (Cd) exposure were studied in male rats. Twenty, 100 day old proven fertile male Sprague-Dawley-rats were assigned to one of four treatment groups and for 70 to 80 days given 0, 17, 34, or 69 parts per million (ppm) Cd as in distilled water. Weekly weight, fluid and food consumption were recorded. At approximately 170 days of age, each male was mated to three female rats, one of which on day 20 of pregnancy was killed for prenatal evaluation. After the third mating each male was killed. Testes and caudal epididymides were removed for histological and spermatogonia evaluation and Cd concentrations in the kidney and liver were determined. Differences in the lower body weights at the higher level of Cd exposure were insignificant. Cd concentrations increased greatly in the kidney, but remained below 200ppm, wet weight needed for detectable renal dysfunction. Male fertility was not affected by the Cd treatment. The authors conclude that Cd orally administered in water concentrations up to 69ppm does not significantly affect reproductive functions. They recommend further reevaluation of the classic view of Cd related testicular injury. [Description provided by NIOSH]
• Subjects:
  Cadmium Laboratories Metals, Heavy Occupational Health Poisoning Safety Sex Characteristics Somatotypes Toxicology Urogenital Diseases
• Keywords:
  Body-distribution Cadmium-poisoning Heavy-metals Laboratory-animals NIOSH-Grant NIOSH-Publication Reproductive-system-disorders Sex-factors
• ISSN:
  0098-4108
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maine ; Ohio ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  377-387
• Volume:
  9
• Issue:
  3
• NIOSHTIC Number:
  nn:00122689
• Citation:
  J Toxicol Environ Health 1982 Mar; 9(3):377-387
• Contact Point Address:
  Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  1982
• NORA Priority Area:
  Reproductive System Disorders
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19810929
• Source Full Name:
  Journal of Toxicology and Environmental Health
• End Date:
  19870831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:87ed2e125c989098961035ecfc1ce5b1ec338c84f130e263b32a637d06f7a4569174a617dfae44b15e7232994259c55235d6227f55e73bfcb19bfbba627f97e6
• Download URL:
  https://stacks.cdc.gov/view/cdc/184545/cdc_184545_DS1.pdf
• File Type:
  [PDF - 729.71 KB ]