Salmonella enterica Serotype Typhi with Nonclassical Quinolone Resistance Phenotype

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Accou-Demartin, Marie ; Gaborieau, Valérie ; Song, Yajun ; Roumagnac, Philippe ; Marchou, Bruno ; Achtman, Mark ; Weill, François-Xavier
• Description:
  We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.
• Subjects:
  Anti-Bacterial Agents Antimicrobial Resistance Bacteria Ciprofloxacin Dispatch Drug Resistance, Bacterial Expedited Gene Expression Regulation, Bacterial Genes, Bacterial GyrB Haplotypes Humans Microbial Sensitivity Tests Mutation Phenotype Quinolones Salmonella Salmonella Typhi Treatment Failure Typhoid Fever

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• Source:
  Emerg Infect Dis. 17(6):1091-1094.
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e1ea5291a0831749f7b89b51a58e811bce28a2255529f1db200315d905e81a92
• Download URL:
  https://stacks.cdc.gov/view/cdc/18451/cdc_18451_DS1.pdf
• File Type:
  [PDF - 391.24 KB ]