Salmonella enterica Serotype Typhi with Nonclassical Quinolone Resistance Phenotype

Accou-Demartin, Marie; Gaborieau, Valérie; Song, Yajun; Roumagnac, Philippe; Marchou, Bruno; Achtman, Mark; Weill, François-Xavier

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Salmonella enterica Serotype Typhi with Nonclassical Quinolone Resistance Phenotype

Jun 2011
By Accou-Demartin, Marie ; Gaborieau, Valérie ; Song, Yajun ; ...
Source: Emerg Infect Dis. 17(6):1091-1094.

[PDF-391.24 KB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Accou-Demartin, Marie ; Gaborieau, Valérie ; Song, Yajun ; Roumagnac, Philippe ; Marchou, Bruno ; ... More +

Accou-Demartin, Marie ; Gaborieau, Valérie ; Song, Yajun ; Roumagnac, Philippe ; Marchou, Bruno ; Achtman, Mark ; Weill, François-Xavier Less -
Description:

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.
Subjects:

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Anti-Bacterial Agents Antimicrobial Resistance Bacteria Ciprofloxacin Dispatch Drug Resistance, Bacterial Expedited Gene Expression Regulation, Bacterial Genes, Bacterial GyrB Haplotypes Humans Microbial Sensitivity Tests Mutation Phenotype Quinolones Salmonella Salmonella Typhi Treatment Failure Typhoid Fever
Source:

Emerg Infect Dis. 17(6):1091-1094.
Document Type:

Journal Article
Volume:

17
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:e1ea5291a0831749f7b89b51a58e811bce28a2255529f1db200315d905e81a92
Download URL:

https://stacks.cdc.gov/view/cdc/18451/cdc_18451_DS1.pdf
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