Salmonella enterica Serotype Typhi with Nonclassical Quinolone Resistance Phenotype
Published Date:Jun 2011
Source:Emerg Infect Dis. 17(6):1091-1094.
Drug Resistance, Bacterial
Gene Expression Regulation, Bacterial
Microbial Sensitivity Tests
Description:We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.
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