Maternal lead exposure inhibits intestinal calcium absorption in rat pups.

Details

• Personal Author:
  Barbe JS ; Knecht EA ; Toraason MA
• Description:
  The effect of maternal lead (7439921) exposure on the development of duodenal calcium (7440702) absorption in rat pups was investigated. Female Sprague-Dawley-rats were fed a diet containing 0.5 percent lead-acetate (301042) for 5 weeks prior to breeding, during gestation, and through day 17 of lactation. Exposure to 0.5 percent lead-acetate diet produced blood lead concentration in the females of between 69 and 84 micrograms per 100 milliliters. The body weights of pups were significantly reduced on days 7 and 16, with the blood lead concentration in pups reaching a maximum on day 16 of lactation. Upon weaning blood lead concentrations declined, and reached a low of 7 micrograms per 100 milliliters by day 30. Calcium absorption on day 20 for lead exposed rats was significantly lower than control values, while by day 30 experimental and control pups showed similar values. The authors suggest that the presence of lead affects some aspect of calcium transport than is enhanced during maturation. [Description provided by NIOSH]
• Subjects:
  Alkalies Digestive System Laboratories Metals Metals, Heavy Occupational Health Safety Toxicology Urogenital System
• Keywords:
  Alkaline-earth-metals Biological-transport Gastrointestinal-system Heavy-metals Laboratory-animals NIOSH-Author Reproductive-effects Transport-mechanisms
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  62-65
• Volume:
  60
• Issue:
  1
• NIOSHTIC Number:
  nn:00120034
• Citation:
  Toxicol Appl Pharmacol 1981 Aug; 60(1):62-65
• CAS Registry Number:
  Calcium (CAS RN 7440-70-2) ; Lead (CAS RN 7439-92-1) ; Lead diacetate (CAS RN 301-04-2)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3790fd2bc4e4db2261679fd8a4c93e4092846cbf4b1eef6c5c4037b1be9c453827989368c6eb7365a7518f5bfa01af0292de44448b9c8d3694d3ced5eb83e3ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/184505/cdc_184505_DS1.pdf
• File Type:
  [PDF - 334.64 KB ]