Detection of Environmental Depigmenting Substances

Details

• Personal Author:
  Gellin, Gerald A. ; Maibach, Howard I. ; Misiaszek, Maria H. ; Ring, Marsha
• Description:
  The depigmenting capacity of some phenols, catechols, and organic antioxidants was studied. Test materials were applied to epilated and unepilated skin sites of black guinea-pigs for 1 to 6 months, and to unepilated dorsal surfaces of black mice for 2 to 4 months. If significant irritation developed, treatment was discontinued until irritation subsided. Biopsies were performed on treated and control sites at the conclusion of treatment. Clear cut depigmentation was seen with monomethyl-ether of hydroquinone (123319), and tertiary-butyl-catechol (27213781) in both guinea-pigs and mice, however the damage was less pronounced in mice. Full depigmentation of the back was seen for p-tertiary-amyl-phenol and of the nipple for monobenzyl-ether of hydroquinone (123319) in guinea-pigs. Application of isopropyl-catechol (28801345), hydroquinone (123319), p-tertiary-butyl-phenol (98544), phenol (108952), and catechol (120809) resulted in moderate depigmentation. False negative responses with known depigmenting chemicals were observed. The authors propose a screening procedure for detecting the depigmenting capacity of medicinal and industrial chemicals, involving the use of five guinea pigs per test agent, chemical application to the back of the animal, use of solvent control groups, and a minimum test period of 60 days. [Description provided by NIOSH]
• Subjects:
  Laboratories Occupational Health Safety Skin Skin Diseases Toxicology
• Keywords:
  Comparative-toxicology Laboratory-animals Medical-screening NIOSH-Grant NIOSH-Publication Pigmentation-disorders Screening-methods Skin-disorders Skin-exposure
• DOI:
  https://doi.org/10.1111/j.1600-0536.1979.tb04853.x
• ISSN:
  0105-1873
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  13 pdf pages
• Volume:
  5
• Issue:
  4
• NIOSHTIC Number:
  nn:00115797
• Citation:
  Contact Dermatitis 1979 Aug; 5(4):201-213
• CAS Registry Number:
  1,2-Benzenediol, (1-methylethyl)- (CAS RN 28801-34-5) ; 4-tert-Butylphenol (CAS RN 98-54-4) ; Catechol (CAS RN 120-80-9) ; Hydroquinone (CAS RN 123-31-9) ; Phenol (CAS RN 108-95-2) ; tert-Butylcatechol (CAS RN 27213-78-1)
• Federal Fiscal Year:
  1979
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  True
• Start Date:
  19740501
• End Date:
  19780430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3cdac3fb4d71a5b761a86ae84f21f9272ce033ad73c13bc6f8c5c3c9c78c0ce7a1f7cb3ff86f028c86e36740dcdb17a10e268b1d4ce7d03fe86fa61585e68128
• Download URL:
  https://stacks.cdc.gov/view/cdc/184444/cdc_184444_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]