Mechanism of occupational leukoderma.

Details

• Personal Author:
  Menter JM
• Description:
  The binding and redox interactions of selected phenolic and catecholic compounds of widely varying potency were studied with model synthetic melanins, melanin-tyrosinase depigmenter (DP) complexes and with melanoproteins extracted from C-57-BL-6-black- mice. Using ferricyanide as an electron acceptor it was demonstrated that DP melanin binding can lead to alterations in electron transfer kinetics, and that the magnitude of such alterations may be roughly correlated with depigmenting potency. Attempts were made to induce hair depigmentation by local subcutaneous or intradermal injection of DPs into black-mice. A possible correlation was sought between DP potency and the behavior of one or more component interactions. The results of these studies will help in early detection and prediction of environmental depigmenters, attainment of a reliable regimen for effecting controlled depigmentation, effective use of the appropriate DP's as chemotherapeutic agents in malignant melanoma, and determination of mechanistic similarities and differences between occupational depigmentation and vitiligo. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Coloring Agents Laboratories Occupational Health Safety Skin Skin Diseases
• Keywords:
  NIOSH-Grant; Laboratory-animals; Pigmentation; Pigments; Pigmentation-disorders; Skin-disorders; Skin-exposure
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Georgia ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:00181250
• NTIS Accession Number:
  PB88247986
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, R01-OH-001556, 1986 Oct; :1-9
• Contact Point Address:
  Biochemistry Morehouse School of Medicine 830 Westrview Drive, SW Atlanta, Georgia 30314
• Federal Fiscal Year:
  1987
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  Morehouse School of Medicine, Atlanta, Georgia
• Peer Reviewed:
  False
• Start Date:
  19820929
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19860331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246116/cdc_246116_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]