Interactions of sulfur dioxide and acrolein as sensory irritants.

Details

• Personal Author:
  Alarie Y ; Kane LE
• Description:
  The effects of sulfur-dioxide (7446095) (SO2) and acrolein (107028) on respiration were evaluated in mice. Swiss-Webster-mice were exposed to 3.4, 1.27 or 0.85 parts per million (ppm) acrolein, 9 to 140ppm SO2, or to a combination of the two in the same individual concentrations. The irritants were introduced into the chamber for 10 minute periods, rates were recorded immediately after the animals breathed room air. The pattern of respiratory response was correlated with the concentration of the irritant. At high SO2 concentrations the response was typical of SO2 and the acrolein effect was blocked. An acrolein type response was observed at high acrolein concentrations. Post exposure recovery after exposure to both irritants was slower than with each irritant alone. The authors conclude that SO2 and acrolein have a ratio dependent antagonistic effect and combined exposure causes a prolongation of irritation after exposure is terminated. [Description provided by NIOSH]
• Subjects:
  Biochemistry Chemistry Laboratories Occupational Health Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Chemical-analysis Chemical-properties Dose-response Laboratory-animals NIOSH-Grant NIOSH-Publication Physiology Pulmonary-system-disorders
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  305-315
• Volume:
  48
• Issue:
  2
• NIOSHTIC Number:
  nn:00107463
• Citation:
  Toxicol Appl Pharmacol 1979 Apr; 48(2):305-315
• Contact Point Address:
  Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
• CAS Registry Number:
  Acrolein (CAS RN 107-02-8) ; Sulfur dioxide (CAS RN 7446-09-5)
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19711001
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19860531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:95a9b25e1fd6ad914ee4e3e1ef7a0091e8fcf617b86dde0157c92a67233ffbc4d771400bbcf79a0a3a16ced89ba7956fa0e611551b605cec6fda1f46df9e1736
• Download URL:
  https://stacks.cdc.gov/view/cdc/184388/cdc_184388_DS1.pdf
• File Type:
  [PDF - 743.33 KB ]