Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Details

• Personal Author:
  Epstein SS ; Infante PF ; Newton WA
• Description:
  Five case reports of neuroblastomas in children, and three cases each of acute leukemia and aplastic anemia associated with exposure to chlordane (57749) are reviewed. Prior literature is reviewed and 25 cases of blood dyscrasia associated with chlordane or heptachlor (76448) are cited. The environmental distribution of chlordane and heptachlor and their appearance in the food chain are reviewed. The authors note that attempts to survey pesticide workers have met with little success because of poor response rates and high turnover in the industry. Because of the environmental accumulation of the agents, humans may be exposed from conception throughout adult life. The authors recommend epidemiologic studies to evaluate health risks associated with both home and occupational uses of chlordane and heptachlor. [Description provided by NIOSH]
• Subjects:
  Biochemistry Carcinogens Chemistry Neoplasms Occupational Health Safety Toxicology
• Keywords:
  Aplastic Anemia Author Keywords: Acute Cancer Chemical-properties Chlordane Leukemia Neuroblastoma NIOSH-Author Physiology
• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Illinois ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  137-150
• Volume:
  4
• Issue:
  2
• NIOSHTIC Number:
  nn:00107209
• Citation:
  Scand J Work Environ Health 1978 Jun; 4(2):137-150
• Contact Point Address:
  Dr. P. F. Infante, Office of Carcinogen Identification and Classification, Occupational Safety and Health Administration, U.S. Department of Labor, 3rd and Constitution Avenue, N.W., Washington, D.C. 20210, U.S.A.
• CAS Registry Number:
  1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene (CAS RN 57-74-9) ; Heptachlor (CAS RN 76-44-8)
• Federal Fiscal Year:
  1978
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2b29ab6d8ab82752485c6d3edc5a87b68906b4cc2922e5a89196aa9e7285624b244b99514256d9f04ef181cac1a823837df007fdc64d92d3a32c8cda3e736e90
• Download URL:
  https://stacks.cdc.gov/view/cdc/184386/cdc_184386_DS1.pdf
• File Type:
  [PDF - 8.49 MB ]