Role of S-Nitrosylation in Apoptosis Resistance and Carcinogenesis

Details

• Personal Author:
  Azad N ; Iyer AKV ; Rojanasakul Y ; Wang LY
• Description:
  Nitric oxide (NO) has been widely recognized as a positive regulator of tumorigenesis and cancer progression through its ability to regulate important proteins in various signal transduction pathways. S-Nitrosylation, or covalent attachment of NO to protein sulphydryl groups, has gained prominence as an important mechanism by which NO modulates physiologic and pathologic cellular responses. In this article, we discuss S-nitrosylation of two key apoptosis-regulatory proteins of the intrinsic and extrinsic death pathways, namely B-cell lymphoma-2 (Bcl-2) and FLICE-inhibitory protein (FLIP). These proteins have been shown to be upregulated in a variety of tumors and have been implicated with cancer chemoresistance through dysregulation of apoptosis, S-Nitrosylation of these proteins precludes their ubiquitination and subsequent degradation by the proteasome, thus accentuating their anti-apoptotic effect which is critical in the context of tumorigenic potential and cancer progression. We propose that such post-translational modifications of proteins by NO may be a general mechanism that tumor cells exploit to tilt the scales towards survival and proliferation by evading cell death. [Description provided by NIOSH]
• Subjects:
  Biochemistry Carcinogens Chemistry Neoplasms Occupational Health Safety
• Keywords:
  Biochemical-analysis Cancer Carcinogenesis Carcinogenicity Cell-alteration Cell-biology Cell-damage Cell-metabolism Cell-transformation Chemical-binding Chemical-reactions Physiological-chemistry Physiological-measurements Physiological-response

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• ISSN:
  1089-8603
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  146-151
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:20034300
• Citation:
  Nitric Oxide 2008 Sep; 19(2):146-151
• Contact Point Address:
  Yon Rojanasakul, Department of Pharmaceutical Sciences, West Virginia University, P.O. Box 9530, Morgantown, WV 26506
• Email:
  yrojan@hsc.wvu.edu
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nitric Oxide: Biology and Chemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e97fe5c383f3dc25401e92027dd139d3c84e3a33e6fa13494f1b1b424776d47835b1983beececde6d2e1accb798c12fb17feb1bf63e1b2f423e63f21546a135e
• Download URL:
  https://stacks.cdc.gov/view/cdc/189553/cdc_189553_DS1.pdf
• File Type:
  [PDF - 144.76 KB ]