Sister chromatid exchange in regenerating liver and bone marrow cells of mice exposed to styrene.

Details

• Personal Author:
  Alarie Y ; Connor MK ; Dombroske RL
• Description:
  The use of a liver preparation for the study of chemically induced sister chromatid exchange (SCE) in-vivo was investigated. Hepatectomized and nonhepatectomized mice were exposed to styrene (100425) by inhalation and the liver and bone marrow regenerating cells were prepared for SCE analysis. SCE frequency was increased 3 to 4 times in the regenerating liver and bone marrow cells. Increases were seen in both nonhepatectomized and hepatectomized mouse cells. The authors conclude that the in-vivo SCE technique is suitable for the study of cytotoxicity in regenerating liver cells. [Description provided by NIOSH]
• Subjects:
  Biochemistry Chromosomes Occupational Health Safety
• Keywords:
  Analytical-methods Cellular-reactions Chromosome-damage Exposure-methods Grants-other NIOSH-Grant NIOSH-Publication Sample-preparation
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  365-367
• Volume:
  50
• Issue:
  2
• NIOSHTIC Number:
  nn:00098193
• Citation:
  Toxicol Appl Pharmacol 1979 Sep; 50(2):365-367
• Contact Point Address:
  Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19711001
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19860531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f911c62996fdff70316e2aefd2e55939db1ce73eef6afe75b23a9aed8ef56a3443ffa1457efbb0b2a6cedadd934f82fdbeb23ba7d3e107f977bdb7e4ece5d5ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/184359/cdc_184359_DS1.pdf
• File Type:
  [PDF - 197.64 KB ]