Does triphenyl phosphate produce delayed neurotoxic effects?

Barron K; Benitz KF; Groblewski GE; Johnson MK; Wills JH

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Does triphenyl phosphate produce delayed neurotoxic effects?

Public Domain

1979/07/01
By Barron K ; Benitz KF ; Groblewski GE ; ...

Details

Personal Author:

Barron K ; Benitz KF ; Groblewski GE ; Johnson MK ; Wills JH
Description:

Neurotoxic effects of triphenyl phosphate (115866) were studied in cats. Cats were given 0.4, 0.7, or 1.0 grams per kilogram of the chemical subcutaneously. The cats were sacrificed and samples of brain stem and spinal cord were taken. Those given the lower dosage did not become ataxic. The higher doses caused prostration some time after dosing, but histological examination did not reveal any evidence of axon degeneration, or demyelination in the spinal cord. The authors conclude that there was no evidence that pure triphenyl phosphate causes delayed neurotoxic effects of the type produced by tri-ortho-cresyl phosphate (78308). [Description provided by NIOSH]
Subjects:

Environmental Exposure Histology Laboratories Nervous System Occupational Exposure Occupational Health Safety
Keywords:

Chemical-exposure Dose-responses Exposure-methods Histological-changes Laboratory-animals Latent-period Neurological-reactions Neurotoxicity NIOSH-Author
ISSN:

0378-4274
Document Type:

Text
Genre:

Journal Article
Place as Subject:

New York ; OSHA Region 2
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

21-24
Volume:

4
Issue:

1
NIOSHTIC Number:

nn:00093670
Citation:

Toxicol Lett 1979 Jul; 4(1):21-24
CAS Registry Number:

o-Cresyl phosphate (CAS RN 78-30-8) ; Triphenyl phosphate (CAS RN 115-86-6)
Federal Fiscal Year:

1979
Peer Reviewed:

True
Source Full Name:

Toxicology Letters
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:cbe847ee8f7ab70b143c1efd69b583a2146b4c85f1c48e960fa7d40b31bbe8eb7a3f1f7b53fd34bef461dc4d69bc2d16f0737ca2af54d338987e58eb4e1daf44
Download URL:

https://stacks.cdc.gov/view/cdc/184336/cdc_184336_DS1.pdf
File Type:

[PDF - 285.07 KB ]

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