Chronic biological effects of methyl methacrylate vapor : III. Histopathology, blood chemistries, and hepatic and ciliary function in the rat.

Details

• Personal Author:
  Hohenleitner FJ ; Kendall FM ; Landin WE ; Oberly R ; Tansy MF ; White DK
• Description:
  The effects of chronic exposure to methyl-methacrylate vapor (80626) (MMA) were studied. Rats were exposed for 56 hours over 7 days to 1,000 parts per million (ppm) of MMA, or to 116 and 400ppm MMA for up to 6 months. Blood and tissue analyses were performed. Mice were exposed intermittently for a total of 160 hours to 100 or 400ppm MMA. Twenty four hours after the final exposure, the mice were injected with 50 milligrams per kilogram of sodium pentobarbital. Sleep onset and duration times were recorded. Frogs were exposed for 61 hours over 7 days to 116 or 400ppm MMA. Mucosal ciliary function was tested. In the exposed rats, some blood chemicals were decreased, but overall blood chemistry did not differ from that of unexposed controls. Histopathological changes were observed in the lungs and tracheal mucosa following 1,000ppm exposure for 56 hours and 116ppm exposure for 6 months, respectively. In the mice, sleep induction time was shorter after 100ppm exposure, and sleep duration time was decreased with 400ppm treatment. Frogs exposed to 400ppm had reduced oropharyngeal transport efficiency. Liver damage occurred in rats and mice at all exposure concentrations. The authors suggest that the alterations of sleep induction and duration in the mice were related to the liver damage. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Digestive System Hematologic Tests Histology Laboratories Liver Nervous System Occupational Health Safety
• Keywords:
  Air-contamination Cellular-reactions Dose-response Gases Hematology Laboratory-animals Liver-function Neurotoxic-effects NIOSH-Grant NIOSH-Publication Physiology

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  117-125
• Volume:
  21
• Issue:
  1
• NIOSHTIC Number:
  nn:00093475
• Citation:
  Environ Res 1980 Feb; 21(1):117-125
• Contact Point Address:
  Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
• CAS Registry Number:
  2-Propenoic acid, 2-methyl-, methyl ester (CAS RN 80-62-6)
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Temple University, Philadelphia, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19740501
• Source Full Name:
  Environmental Research
• End Date:
  19810331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3b76be6fa32bf13df0a387942cd7914946e01372113bdbea923a7bbd45c449f1475dd28e790bb975de55f92f23869ddc0a0400234021a46f93b1a09534d80d04
• Download URL:
  https://stacks.cdc.gov/view/cdc/184324/cdc_184324_DS1.pdf
• File Type:
  [PDF - 3.91 MB ]