Update on the toxicity of inhaled methyl methacrylate vapor.

Details

• Personal Author:
  Kendall FM ; Tansy MF
• Description:
  Information on the acute and chronic effects of methyl-methacrylate vapor (80626) (MMA) exposure is reviewed. Experimental results are included for studies on median lethal dose, subchronic toxicity, body weight and gross metabolic performance, blood chemistry, and cardiovascular response. Also reviewed are findings on central nervous system effects, histopathology, teratology, and gastrointestinal motility. The authors conclude that no data presently exists to indicate that routine occupational exposures to MMA are hazardous. Available information does suggest that low concentrations of the vapor can affect gastrointestinal motility. MMA is a powerful irritant and can induce cellular response. The authors recommend that the adequacy of the threshold limit value for MMA be evaluated on the basis of the cellular responses. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Nervous System Occupational Health Safety
• Keywords:
  Air-contamination Cellular-reactions Dose-response Gases Lethal-concentrations Neurotoxic-effects NIOSH-Grant NIOSH-Publication Physiology Standards
• ISSN:
  0148-0545
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  315-330
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:00093168
• Citation:
  Drug Chem Toxicol 1979; 2(4):315-330
• Contact Point Address:
  Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
• CAS Registry Number:
  2-Propenoic acid, 2-methyl-, methyl ester (CAS RN 80-62-6)
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Temple University, Philadelphia, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19740501
• Source Full Name:
  Drug and Chemical Toxicology
• End Date:
  19810331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c62f3fa45e14a78a91ce8b10145ef097f2dc8ed053db32a57c45794d5ff3d06222bf517cee2a30223c019a3f8ed76562db39f4535780dbd2bd39e18326c0c3af
• Download URL:
  https://stacks.cdc.gov/view/cdc/184317/cdc_184317_DS1.pdf
• File Type:
  [PDF - 674.28 KB ]