An epidemic of urinary retention caused by dimethylaminopropionitrile.

Details

• Personal Author:
  Keogh, James P. ; Moreland R ; Pestronk A ; Wertheimer D
• Description:
  Employees at two polyurethane (68400679) manufacturing facilities were surveyed to determine the extent of urinary dysfunction due to dimethylaminopropionitrile (1738256) (DMAPN) exposure. Questionnaires were given to 141 workers at facility A and 75 workers at facility B to identify symptoms related to the skin, lungs, central nervous system, or urogenital system. All workers were given a complete physical examination, lung function tests, and blood and urine analyses. Workers with persistent symptoms of urinary retention were given intravenous pyelography tests. Symptoms of urinary retention among workers at both facilities included straining, hesitancy, decreased flow, intermittent flow, bladder distension, and the need for manual pressure to empty the bladder. Increased incidence of urinary retention, muscle weakness, paresthesia, insomnia, and sexual dysfunction also was found among exposed workers. Results of blood and urine analyses were normal. After removal of a catalytic agent containing DMAPN, no new cases were reported. The authors suggest that new and previously used chemicals should be studied for their potential toxicity in industrial use. Symptoms that an employee thinks may be work related should be thoroughly investigated. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Manufacturing And Industrial Facilities Nervous System Nervous System Diseases Occupational Exposure Occupational Health Plastics Safety Urogenital Diseases Urogenital System
• Keywords:
  Body-retention Chemical-exposure Chemical-factory-workers Contract-210-78-0014 Industrial-operations Neurological-disorders Neurotoxicity NIOSH-Contract NIOSH-Publication Physiological-response Plastic-materials Urogenital-system-disorders

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• ISSN:
  0098-7484
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  243
• Issue:
  8
• NIOSHTIC Number:
  nn:00092989
• Citation:
  JAMA 1980 Feb; 243(8):746-749
• Contact Point Address:
  Dr. Keogh, Baltimore City Hospitals, 4940 Eastern Ave, Baltimore, MD 21224
• CAS Registry Number:
  1,3-Butanediol, polymer with α-butyl-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and 1,3-diisocyanatomethylbenzene (CAS RN 68400-67-9) ; Dimethylaminopropionitrile (CAS RN 1738-25-6)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  True
• Source Full Name:
  Journal of the American Medical Association
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:85adf9f40c1f678a3841efffd200135314ff9b7d184a9db1ab638ef755b27508a15bbd542cad7e838a93976291c533328f812fcb5f26e9c15bbf74fd75374bc1
• Download URL:
  https://stacks.cdc.gov/view/cdc/184313/cdc_184313_DS1.pdf
• File Type:
  [PDF - 572.39 KB ]