Clinical epidemiology of occupational neurotoxic disease.

Details

• Personal Author:
  Feldman RG ; Heath CW Jr. ; Kreiss, Kathleen ; Landrigan, Philip J. ; Xintaras, Charles
• Description:
  The clinical and epidemiological features of three outbreaks of neurologic diseases among workers in the United States caused by environmental exposure to neurotoxic chemicals are reviewed. The chemicals are Kepone (143500), dimethylaminopropionitrile (1738256) (DMAPN) and methyl-butyl-ketone (591786) (MBK). The symptoms and frequency of occurrences of cases, the categories of workers, incidence of exposure, the source of exposure and manner of detection are described. The authors suggest that many small isolated outbreaks of neurologic disease of obscure origin may be due to occupational or environmental exposure to neurotoxic chemicals. They conclude that recognition of the etiology of chemically induced neurologic illness and isolation of new neurotoxic syndromes from the mass of neurologic illness of undetermined origin will require a high index of clinical suspicion, careful ascertainment of occupational history, and a sensitivity to epidemiologic factors. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Epidemiology Hazardous Substances Insecticides Manufacturing And Industrial Facilities Nervous System Nervous System Diseases Occupational Exposure Occupational Health Safety Workplace

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• Keywords:
  NIOSH-Publication; NIOSH-Grant; Pesticides-and-agricultural-chemicals; Epidemiology; Neurological-disorders; Toxic-substances; Chemical-exposure; Industrial-factory-workers; Work-environment; Neurotoxicity
• ISSN:
  0191-3581
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  43-48
• Volume:
  2
• Issue:
  1
• NIOSHTIC Number:
  nn:00097189
• Citation:
  Neurobehav Toxicol 1980 Jan; 2(1):43-48
• Contact Point Address:
  Neurology University Hospital 75 East Newton Street Boston, Mass 02118
• CAS Registry Number:
  2-Hexanone (CAS RN 591-78-6) ; Chlordecone (CAS RN 143-50-0) ; Dimethylaminopropionitrile (CAS RN 1738-25-6)
• Federal Fiscal Year:
  1980
• Performing Organization:
  University Hospital (Boston), Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19800401
• Source Full Name:
  Neurobehavioral Toxicology
• End Date:
  19830331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241096/cdc_241096_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]