Neurological dysfunction of the bladder in workers exposed to dimethylaminopropionitrile.

Details

• Personal Author:
  Feldman RG ; Krane RJ ; Kreiss, Kathleen ; Niles CA ; Siroky MB ; Wegman, David H.
• Description:
  An outbreak of bladder dysfunction among workers at a polyurethane (68400679) foam manufacturing factory in Massachusetts was investigated. Interviews were conducted with 208 employees about their job descriptions, use of protective clothing, and medical symptoms. Neurologic evaluations were performed on eight symptomatic workers. Symptoms were identified among 104 workers, most of whom worked at the production line. The workers reported hesitancy, the need to strain at urination, decreased urinary stream, and increased duration of urination. Some reported pain or discomfort. Symptoms or incidence were not sex related. Sexual difficulties also were reported. Sensory and sensorimotor neuropathy were found in seven of the eight affected workers that were tested. The onset of this epidemic was associated with the introduction of dimethylaminopropionitrile (1738256) (DMAPN) into the production process. When DMAPN was removed from the process, symptoms ceased abruptly, and no new outbreaks were reported. The authors conclude that DMAPN produces bladder dysfunction without producing frequent complaints of other organ or nerve dysfunction. They suggest that the mechanism of DMAPN action needs to be studied in animals. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Epidemiology Hazardous Substances Manufacturing And Industrial Facilities Nervous System Nervous System Diseases Occupational Exposure Occupational Health Plastics Safety Sense Organs Urogenital Diseases Urogenital System

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• Keywords:
  Chemical-exposure Chemical-factory-workers Contract-210-78-0015 Neurological-disorders Neurotoxicity NIOSH-Contract NIOSH-Publication Plastic-materials Recovery-time Sensory-perceptual-disorders Toxic-substances Urogenital-system-disorders

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• ISSN:
  0098-7484
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  243
• Issue:
  8
• NIOSHTIC Number:
  nn:00092988
• Citation:
  JAMA 1980 Feb; 243(8):741-745
• Contact Point Address:
  Dr Wegman, Occupational Health Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
• CAS Registry Number:
  1,3-Butanediol, polymer with α-butyl-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and 1,3-diisocyanatomethylbenzene (CAS RN 68400-67-9) ; Dimethylaminopropionitrile (CAS RN 1738-25-6)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  True
• Source Full Name:
  Journal of the American Medical Association
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:352575231744cf7287cf3176ba6788d6c8ca0fffaa9b758106ac1931f3ab025ff602367511ee5f8aef89d9559ed5cba852dfe61d2b47c15cbf8bd474ffcb7765
• Download URL:
  https://stacks.cdc.gov/view/cdc/184312/cdc_184312_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]