Distal axonopathy: one common type of neurotoxic lesion.

Details

• Personal Author:
  Schaumburg HH ; Spencer PS
• Description:
  The morphological aspects of neurotoxicity and the principles of testing for the detection of neurotoxic diseases such as distal axonopathies were evaluated. Methodology for establishing normative data for nerve fibers and cells were examined and a listing of toxic chemicals producing structural damage to the nervous system and pathological responses was compiled. Clinical response studies on chronic systemic intoxication of neurotoxic chemicals or drugs were reviewed. A new test for neurotoxicity that is based on the examination of selected areas of brain and nerve tissues was developed. Similarities between neurotoxic pathological expressions and naturally occurring neuropathies associated with human disease and the aging process also were considered. [Description provided by NIOSH]
• Subjects:
  Environmental Pollution Laboratories Nervous System Occupational Health Safety
• Keywords:
  Clinical-studies Environmental-contamination Histopathology Laboratory-animals Morphology Neurotoxic-effects Neurotoxins NIOSH-Grant NIOSH-Publication
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  97-105
• Volume:
  26
• NIOSHTIC Number:
  nn:00091750
• Citation:
  Environ Health Perspect 1978 Oct; 26:97-105
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5fcd998ae721870d2fa28ad8a9a217efa74e2ecab2509e388d3c4726d110c83546d91f938c5a6b0b932d5374a5c1fcbc5d132f3d9b82f052676da7513265e6ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/184279/cdc_184279_DS1.pdf
• File Type:
  [PDF - 4.56 MB ]