Toxic models of disorders of the peripheral nervous system.

Details

• Personal Author:
  Schaumburg HH ; Spencer PS
• Description:
  Human neuropathies that are analogous to reactions produced in laboratory animals by the administration of exogenous toxins are described. Three kinds of pathological reactions (primarily of the peripheral nervous system) to exogenous toxins are: nerve cell death (toxic neuropathy), primary demyelination (toxic myelinopathy), and axonal degeneration (toxic axonopathy). Peripheral nervous system axonopathies are divided into the common distal central and peripheral type, and the rare proximal type. Pathological reactions are discussed in terms of which nerve part is affected by the toxin, symptoms of pathology, results of animal experimentation with specific toxins, and how these results may affect the study of human neuropathies. The author describes the close relationship between animal studies that provided a valid morphological rationale for toxic distal central and peripheral axonopathies and human toxic reactions. [Description provided by NIOSH]
• Subjects:
  Biochemistry Laboratories Manufacturing And Industrial Facilities Mental Health Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neurotoxicity; Neurotoxins; Laboratory-animals; Neuropathology; Psychological-factors; Peripheral-nervous-system; Physiological-systems; Biochemical-reactions; Chemical-workers; Histopathology; Research-laboratories
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-6
• NIOSHTIC Number:
  nn:00091805
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, R01-OH-000535, 1979 Jan; :1-6
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York
• Peer Reviewed:
  False
• Start Date:
  19751101
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246029/cdc_246029_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]