Peripheral nerve abnormalities in aging rats

Details

• Personal Author:
  Grover-Johnson N ; Spencer PS
• Description:
  Ultrastructural abnormalities found in sciatic, tibial and plantar nerves of rats from 3 months to 2.5 years of age were investigated. Morphological abnormalities were evident in all the nerves examined regardless of whether the animals had been housed on wire mesh or on smooth floors. The degree and proximal spread of abnormality increased as a function of age and body weight. Aberrant findings were encountered with increasing frequency on descent from the sciatic to the tibial nerve in the lower hindlimb, being most prominent in the lateral and medial plantar nerves. Contorted and infolded myelin sheaths were noted on most of the plantar nerve fibers. Myelinated fibers with a corrugated surface and deeply infolded myelin sheath were common. Normal and abnormal configurations of unmyelinated fibers were also found including fibers with redundant cytoplasmic processes, reduplicated basal lamina, or encircling supernumerary Schwann cell processes. Collagen and elastin fibers were prominent in the endoneurial compartment. Endoneurial cells other than fibroblasts or mast cells were found sometimes adjacent to nerve fibers or blood vessels. The authors concluded that the abnormalities encountered in the sciatic, tibial and plantar nerves of aging rodents must be considered when evaluating the results of a long term experiment. [Description provided by NIOSH]
• Subjects:
  Age Factors Laboratories Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Age-factors Laboratory-animals Morphology Nervous-system-disorders Neurotoxic-effects NIOSH-Grant NIOSH-Publication
• ISSN:
  0022-3069
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  155-165
• Volume:
  40
• Issue:
  2
• NIOSHTIC Number:
  nn:00185867
• Citation:
  J Neuropathol Exp Neurol 1981 Mar; 40(2):155-165
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• Federal Fiscal Year:
  1981
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Journal of Neuropathology and Experimental Neurology
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:84af2c5959ce6f1931ec4af4e9807ac68987cec9c6d167542abd1d03c21003b4962472a1c8cd16dcee8bc416aadfb2c2421a3eb68bb28f7749c3df55daa20f49
• Download URL:
  https://stacks.cdc.gov/view/cdc/205349/cdc_205349_DS1.pdf
• File Type:
  [PDF - 483.21 KB ]